FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W987526355> ?p ?o ?g. }

• W987526355 abstract "Abstract Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but its role in neuropathic pain remains unclear. In this study, we examined the ER stress and the unfolded protein response (UPR) activation in a L5 spinal nerve ligation (SNL)-induced rat neuropathic pain model. SNL-induced neuropathic pain was assessed behaviorally using the CatWalk system and histologically with microglial activation in the dorsal spinal horn. L5 SNL induced BIP upregulation in the neuron of superficial laminae of dorsal spinal horn. It also increased the level of ATF6 and intracellular localization into the nuclei in the neurons. Moreover, spliced XBP1 was also markedly elevated in the ipsilateral spinal dorsal horn. The PERK-elF2 pathway was activated in astrocytes of the spinal dorsal horn in the SNL model. In addition, electron microscopy revealed the presence of swollen cisternae in the dorsal spinal cord after SNL. Additionally, inhibition of the ATF6 pathway by intrathecal treatment with ATF6 siRNA reduced pain behaviors and BIP expression in the dorsal horn. The results suggest that ER stress might be involved in the induction and maintenance of neuropathic pain. Furthermore, a disturbance in UPR signaling may render the spinal neurons vulnerable to peripheral nerve injury or neuropathic pain stimuli." @default.
• W987526355 created "2016-06-24" @default.
• W987526355 creator A5008383067 @default.
• W987526355 creator A5013947041 @default.
• W987526355 creator A5027155147 @default.
• W987526355 creator A5029833906 @default.
• W987526355 creator A5031290671 @default.
• W987526355 creator A5034226548 @default.
• W987526355 creator A5036037840 @default.
• W987526355 creator A5049466193 @default.
• W987526355 creator A5055930114 @default.
• W987526355 creator A5057635837 @default.
• W987526355 creator A5073807993 @default.
• W987526355 creator A5075200035 @default.
• W987526355 creator A5077093336 @default.
• W987526355 creator A5084587511 @default.
• W987526355 date "2015-06-25" @default.
• W987526355 modified "2023-10-14" @default.
• W987526355 title "Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model" @default.
• W987526355 cites W1970101770 @default.
• W987526355 cites W1978999653 @default.
• W987526355 cites W1980942517 @default.
• W987526355 cites W1983315072 @default.
• W987526355 cites W1990057935 @default.
• W987526355 cites W1990979658 @default.
• W987526355 cites W1994044388 @default.
• W987526355 cites W1997369314 @default.
• W987526355 cites W2004465970 @default.
• W987526355 cites W2007157911 @default.
• W987526355 cites W2012369847 @default.
• W987526355 cites W2016040396 @default.
• W987526355 cites W2024302061 @default.
• W987526355 cites W2025846979 @default.
• W987526355 cites W2033149248 @default.
• W987526355 cites W2037657846 @default.
• W987526355 cites W2043882563 @default.
• W987526355 cites W2044241702 @default.
• W987526355 cites W2045109757 @default.
• W987526355 cites W2047498253 @default.
• W987526355 cites W2052034388 @default.
• W987526355 cites W2060574598 @default.
• W987526355 cites W2062918974 @default.
• W987526355 cites W2081562696 @default.
• W987526355 cites W2090998770 @default.
• W987526355 cites W2113935443 @default.
• W987526355 cites W2117875646 @default.
• W987526355 cites W2120736516 @default.
• W987526355 cites W2126859035 @default.
• W987526355 cites W2127031103 @default.
• W987526355 cites W2127916470 @default.
• W987526355 cites W2152398979 @default.
• W987526355 cites W2158959097 @default.
• W987526355 cites W2162797237 @default.
• W987526355 cites W4250374989 @default.
• W987526355 doi "https://doi.org/10.1038/srep11555" @default.
• W987526355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4479804" @default.
• W987526355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26109318" @default.
• W987526355 hasPublicationYear "2015" @default.
• W987526355 type Work @default.
• W987526355 sameAs 987526355 @default.
• W987526355 citedByCount "45" @default.
• W987526355 countsByYear W9875263552016 @default.
• W987526355 countsByYear W9875263552017 @default.
• W987526355 countsByYear W9875263552018 @default.
• W987526355 countsByYear W9875263552019 @default.
• W987526355 countsByYear W9875263552020 @default.
• W987526355 countsByYear W9875263552021 @default.
• W987526355 countsByYear W9875263552022 @default.
• W987526355 countsByYear W9875263552023 @default.
• W987526355 crossrefType "journal-article" @default.
• W987526355 hasAuthorship W987526355A5008383067 @default.
• W987526355 hasAuthorship W987526355A5013947041 @default.
• W987526355 hasAuthorship W987526355A5027155147 @default.
• W987526355 hasAuthorship W987526355A5029833906 @default.
• W987526355 hasAuthorship W987526355A5031290671 @default.
• W987526355 hasAuthorship W987526355A5034226548 @default.
• W987526355 hasAuthorship W987526355A5036037840 @default.
• W987526355 hasAuthorship W987526355A5049466193 @default.
• W987526355 hasAuthorship W987526355A5055930114 @default.
• W987526355 hasAuthorship W987526355A5057635837 @default.
• W987526355 hasAuthorship W987526355A5073807993 @default.
• W987526355 hasAuthorship W987526355A5075200035 @default.
• W987526355 hasAuthorship W987526355A5077093336 @default.
• W987526355 hasAuthorship W987526355A5084587511 @default.
• W987526355 hasBestOaLocation W9875263551 @default.
• W987526355 hasConcept C104317684 @default.
• W987526355 hasConcept C118552586 @default.
• W987526355 hasConcept C127561419 @default.
• W987526355 hasConcept C139447449 @default.
• W987526355 hasConcept C158617107 @default.
• W987526355 hasConcept C169760540 @default.
• W987526355 hasConcept C185592680 @default.
• W987526355 hasConcept C2777107010 @default.
• W987526355 hasConcept C2780775167 @default.
• W987526355 hasConcept C42219234 @default.
• W987526355 hasConcept C55493867 @default.
• W987526355 hasConcept C71924100 @default.
• W987526355 hasConcept C86803240 @default.
• W987526355 hasConcept C95444343 @default.
• W987526355 hasConceptScore W987526355C104317684 @default.

• next