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- W98765121 abstract "Radiation is the foundation of treatment for locally advanced non-small cell lung cancer (NSCLC), and as such, optimal radiation dose is essential for successful treatment. This article will briefly review biological considerations of radiation dose and their effect in the context of three-dimensional conformal radiation therapy (3D-CRT) including intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) for NSCLC. It will focus on literature review and discussions regarding radiation dose effect in locally advanced NSCLC including potential severe and lethal toxicities of high dose radiation given with concurrent chemotherapy. Potential new approaches for delivering safe and effective doses by individualizing treatment based on functional imaging are being applied in studies such as the PET boost trial and RTOG1106. The RTOG concept of delivering high dose radiation to the more resistant tumors with the use of isotoxic dose prescription and adaptive planning will also be discussed in detail." @default.
- W98765121 created "2016-06-24" @default.
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- W98765121 date "2014-04-01" @default.
- W98765121 modified "2023-09-29" @default.
- W98765121 title "Radiation dose effect in locally advanced non-small cell lung cancer." @default.
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- W98765121 doi "https://doi.org/10.3978/j.issn.2072-1439.2014.01.23" @default.
- W98765121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3968556" @default.
- W98765121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24688778" @default.
- W98765121 hasPublicationYear "2014" @default.
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