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- W987656780 abstract "Publisher Summary This chapter presents a number of methods that are available for establishing long-term lymphoid cultures. Most long-term lymphoid cell lines from chromosomally normal individuals maintain a diploid or near diploid number for long periods of time. Some diploid cell lines, however, do become heteroploid after being in continuous culture. Aneuploidy occurs more frequently in cell lines derived from donors with malignant diseases and infectious mononucleosis. Selective growth advantage may occur among competing cell lines. Lymphoid cell lines are well suited for the biochemical studies of normal and abnormal metabolic pathways. Long-term lymphoid cells are intensively studied because of the usual nature of these cells for immunologic analysis. The cells have the capacity for synthesizing and secreting a large variety of products of immunologic significance. These cell cultures are used for evaluating mediators of delayed hypersensitivity, such as migration inhibitory factor, skin reactive factor, lymphotoxin factor, blastogenic factor, chemotactic factors, and interferon." @default.
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- W987656780 date "1979-01-01" @default.
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- W987656780 title "Long-Term Lymphoid Cell Cultures" @default.
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- W987656780 doi "https://doi.org/10.1016/s0074-7696(08)60611-7" @default.
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