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- W98776504 abstract "Epileptic activity and seizures represent highly dynamic phenomena potentially activating brain tissue in various regions of the brain. Analyzing such epileptiform activity, and the pathways through which it spreads, requires tools that provide both excellent temporal and spatial resolution. Optical imaging is capable of yielding information on this scale and is therefore well-suited to study the onset and spread of seizure activity. There are two main forms of optical imaging. ‘Extrinsic’ optical imaging relies on the use of indicators that change their optical properties (e.g., fluorescence or absorbance) with variations in cellular activity (i.e., changes in neuronal membrane potential). With the use of voltage sensitive dyes, temporal resolution is excellent (within milliseconds), but as dyes are toxic, this approach is used in experimental studies only. In contrast, ‘intrinsic’ optical imaging is based on signal changes associated with tissue itself and is entirely noninvasive. This article deals with intrinsic optical imaging and its relevance to the study of different forms of epileptic activity, including their regions of onset and spread, with special consideration of experimental studies carried out in the brain slice preparation, in vitro." @default.
- W98776504 created "2016-06-24" @default.
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- W98776504 date "2009-01-01" @default.
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- W98776504 title "IMAGING | Using Intrinsic Optical Signal Changes to Analyze Epileptic Activity and Seizures" @default.
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- W98776504 doi "https://doi.org/10.1016/b978-012373961-2.00245-9" @default.
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