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- W988714302 abstract "Although hypertension is an important cardiovascular risk factor, clinical trials [1–8] have shown that the blood pressure reduction induced by antihypertensive drugs is not followed by an equivalent improvement in the incidence and severity of coronary insufficiency. This fact, one of the hardest to understand in the treatment of hypertension, raises several questions. First, it is possible that the entry criteria in the different therapeutic trials played a role in the incidence of coronary insufficiency in hypertensive patients. Second, coronary ischemia is undoubtedly related to alterations in large coronary arteries. This finding is partly unexpected since it is commonly believed that hypertensive vascular disease is exclusively due to a reduction in the caliber of small arteries, and does not involve modifications of large vessels." @default.
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- W988714302 date "1989-01-01" @default.
- W988714302 modified "2023-09-27" @default.
- W988714302 title "Clinical trials, coronary insufficiency, and large arteries in hypertension" @default.
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- W988714302 doi "https://doi.org/10.1007/978-94-009-0941-0_25" @default.
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