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• W988880120 abstract "Apolipoprotein C1 (ApoC1) is a component of multiple lipoproteins where it performs a variety of roles in lipid metabolism and transport. ApoC1 exists as both full-length and truncated isoforms. Truncation of ApoC1 has been postulated to result from the action of dipeptidyl peptidase-4 (DPP-4), the target of a new class of diabetes drugs that includes sitagliptin phosphate. In this study, we sought to determine if oral administration of sitagliptin altered the proportion of ApoC1 isoforms circulating in humans. Results indicated a dramatic change in ApoC1 truncation, consistent with a high level of DPP-4 inhibition by sitagliptin. Funding: University of Minnesota, Minneapolis, MN, USA." @default.
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• W988880120 date "2015-07-22" @default.
• W988880120 modified "2023-10-11" @default.
• W988880120 title "Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1" @default.
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• W988880120 doi "https://doi.org/10.1007/s13300-015-0123-1" @default.
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