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- W988883331 abstract "目的 探讨RNA干扰乏氧诱导因子-1a(HIE-1a)对人肺腺癌细胞SPCA-1摄取^18F-脱氧葡萄糖(FDG)的影响。方法构建干扰HIE-1a质粒pSUPER-HIF-1a，采用荧光定量逆转录．聚合酶链反应(RT-PCR)、Western印迹法观察有氧与乏氧状态下RNA干扰后HIF-1a的变化，用γ计数仪检测其对SPCA-1细胞摄取^18F-FDG的影响。结果 RNA干扰HIF-1a，在乏氧和常氧状态下致mRNA表达分别下降76％和64％，空载体对照组分别为5％和0％；在乏氧状态下，蛋白质的表达下降，SPCA-1细胞对^18F-FDG的摄取明显降低(P<0．05)。结论在乏氧状态下，RNA干扰HIF-1a明显降低SPCA-1细胞对^18F-FDG的摄取。" @default.
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- W988883331 date "2005-06-25" @default.
- W988883331 modified "2023-09-25" @default.
- W988883331 title "RNA干扰HIF—1a对人肺腺癌细胞SPCA-1摄取^18F—FDG的影响" @default.
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