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- W98892425 abstract "This chapter discusses the role of serum total haemolytic complement in liver disease. Complement consists of nine components made up from 11 distinct serum proteins. These components exist in the serum in the form of precursors and are converted to the active form after interaction with immune complexes. Elevation of complement levels in cases of cholangitis or with primary or secondary hepatic tumor and in some cases of cirrhosis might be because of increased synthesis of complement. This occurs with infections or inflammation in other sites. Decrease in synthesis of complement is the explanation for the low levels in acute hepatic necrosis. Increased utilization of complement through fixation by circulating or trapped immune complexes, or through fixation by antibody to cell or tissue antigens, might account for the low levels in active chronic hepatitis and primary biliary cirrhosis. The problem in studies of this kind is to differentiate between increased consumption of complement and decreased synthesis." @default.
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- W98892425 date "1971-01-01" @default.
- W98892425 modified "2023-09-26" @default.
- W98892425 title "SERUM TOTAL HAEMOLYTIC COMPLEMENT IN LIVER DISEASE" @default.
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- W98892425 doi "https://doi.org/10.1016/b978-0-433-30725-9.50017-3" @default.
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