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- W989425566 abstract "Mutations of p53 are common in a wide spectrum of tumors.1 They occur commonly in both non-small cell lung cancer (NSCLC) and small cell lung cancer cell lung cancer (SCLC), as well as breast, colon, head and neck, esophageal, hepatocellular and brain cancers.2,3 The precise role of these mutations in oncogenesis and the mechanisms involved are subjects of active investigation. The type of mutation found in many cancers suggests the mutations are caused by the interaction of DNA with a specific carcinogen.4 For example, mutations in p53 positively correlate with lifetime cigarette consumption.5 Radon exposure, which increases lung cancer risk, is also associated with p53 mutations, although the types of mutations differ from those seen in tobacco-associated lung cancer.6 Insertion of a wild-type p53 into lung cancer and colon cancer cell lines with a mutant or deleted p53 can suppress their growth even though the cells have multiple genetic lesions.7–9 The p53 protein may be overexpressed in lung cancer cells, although this is not always associated with the presence of a mutant p53 gene. However, overexpression of the p53 protein has correlated positively with a poor prognosis for some cancers.10,11 Deletions in 17p, p53 mutations, and 3p deletions have been detected in preneoplastic lesions of the lung such as severe dysplasia.12 Mutations in p53 and the ras oncogene appear to be independent events.13 Mutations in the p53 gene may have significance for several aspects of the clinical practice of oncology including cancer diagnosis, prognosis and staging, prevention and treatment, and these will be discussed in this chapter.KeywordsHuman Lung CancerAerodigestive TractPremalignant LesionHuman Lung Cancer CellMulticellular Tumor SpheroidThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W989425566 date "1995-01-01" @default.
- W989425566 modified "2023-09-24" @default.
- W989425566 title "Potential Clinical Significance of the p53 Tumor Suppressor Gene in Cancer Patients" @default.
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- W989425566 doi "https://doi.org/10.1007/978-3-662-22275-1_6" @default.
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