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- W989485696 abstract "Extranodal marginal zone lymphoma (MALT lymphoma) comprises approximately 8 % of non-Hodgkin’s lymphomas. Recurrent karyotype abnormalities, despite involving different genes, appear to affect the same signalling pathway, resulting in the activation of nuclear factor-kappa B (NF-κB). The most common site of MALT lymphoma is the stomach, although involvement may occur at any other site. MALT lymphomas mostly arise at sites normally devoid of lymphoid tissue and are often preceded by chronic inflammatory conditions. There is a convincing evidence of the pathogenetic role of Helicobacter pylori in gastric lymphoma, and other infectious agents may also have a pathogenetic role in other anatomical sites. H. pylori eradication with antibiotics can lead to the regression of localized gastric MALT lymphoma in over 75 % of patients. Treatment of non-gastric localizations with antibiotics remains mainly investigational. Patients who do not respond to antibiotic therapy may be considered for localized radiotherapy. Chemotherapy and immunotherapy can be effective in patients with disseminated disease. Several active drugs have been tested in phase II trials. The efficacy of the combination of rituximab with chlorambucil in either non-gastric or gastric antibiotic-resistant MALT lymphoma has been shown in a randomized study. Aggressive anthracycline-containing regimens are not usually necessary and should be reserved for the few patients with high tumor burden and for those with diffuse large-cell infiltration. These latter, indeed, should be treated according to the recommendations for diffuse large-cell lymphoma." @default.
- W989485696 created "2016-06-24" @default.
- W989485696 creator A5009234092 @default.
- W989485696 creator A5049503939 @default.
- W989485696 creator A5066518317 @default.
- W989485696 date "2013-01-01" @default.
- W989485696 modified "2023-09-26" @default.
- W989485696 title "MALT Lymphoma (Extranodal Marginal Zone B-Cell Lymphoma)" @default.
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