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- W989689615 abstract "This chapter emphasizes on the importance of measuring health-related quality of life (QoL) as one of several valid indicators of whether treatment with growth hormone (GH) is beneficial. There are two main types of health-related QoL measures namely, disease specific and generic. A combination is generally advocated, as each provides complementary information. However, it is mandatory that the questionnaires are validated correctly and that tests in the relevant language with a sufficient population-based reference group are available. This chapter also reviews some clinical studies of effects of GH replacement therapy on QoL in adults, and the therapeutic mechanisms of GH replacement are discussed. Although many of the studies performed to assess QoL and GH replacement are not long enough, not controlled, or use too high GH dose or the wrong QoL instruments, a growing body of evidence for an impairment of QoL in GH-deficient patients and an improvement or normalization after GH replacement exists." @default.
- W989689615 created "2016-06-24" @default.
- W989689615 creator A5085122960 @default.
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- W989689615 date "2006-01-01" @default.
- W989689615 modified "2023-09-27" @default.
- W989689615 title "Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality" @default.
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- W989689615 doi "https://doi.org/10.1016/b978-012088484-1/50021-5" @default.
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