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- W989814147 abstract "AIM: To detect the expression of 14-3-3 gene family members in hepatocellular carcinoma (HCC) by GeneChip and determine its clinical significance. METHODS: Total RNA was isolated from tissue of HCC, liver cirrhosis and normal liver, purified into mRNA by Oligotex, and reverse-transcribed to synthesize two kinds of fluorescently labeled cDNA probes (Cy3-dUTP, Cy5-dUTP). The targets were mixed together and hybridized by GeneChip. The expression of 14-3-3 gene family members among different liver tissues was detected based on signal-to-noise ratios by using GenePix Pro3.0 software, the outcome was verified by semi-quantitative RT-PCR, and the clinical significance of differentially expressed genes was explored. RESULTS: 14-3-3 gene family members were expressed differently in HCC, 14-3-3γ was down-regulated and closely related to the integrity of the envelope of the tumor. 14-3-3η was up-regulated in HCC and had a close relationship to the clinical stage of HCC. A negative correlation was found between l4-3-3γ and 14-3-3η mRNA expression (γ=-0.403, P＜0.05). CONCLUSION: Dysfunction of the regulatory mechanism of the 14-3-3 gene family may play a crucial role in the development of HCC. 14-3-3γ and 14-3-3η are closely related to HCC." @default.
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- W989814147 date "2007-11-08" @default.
- W989814147 modified "2023-09-24" @default.
- W989814147 title "肝癌组织中14-3-3基因差异表达的意义" @default.
- W989814147 hasPublicationYear "2007" @default.
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