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- W989895499 abstract "目的观察淫羊藿苷在体外试验中对α-突触核蛋白（α-synuclein,α-Syn）及相关蛋白表达的影响及其作用机制。方法 不同浓度的淫羊藿苷与转染α-Syn基因PC12细胞共孵育24h,应用RT-PCR法检测各组细胞α-Syn mRNA含量,Western免疫印迹法检测细胞中α-Syn、泛素化蛋白羧基端水解酶（Ubiquitin C-terminal hydrolase protein,UCH-L1）和Parkin蛋白的表达,观察淫羊藿苷对它们的影响。结果 淫羊藿苷浓度40～80μmol/L与转染α-Syn基因细胞孵育24h,能够明显减少模型细胞中α-SynmRNA含量,抑制Syn蛋白表达和聚集,增强UCH-L1和Parkin蛋白表达。结论 淫羊藿苷在体外对基因转染细胞的α-Syn过表达和聚集有明显抑制作用,其作用机制与抑制α-Syn合成和增强α-Syn降解有关。" @default.
- W989895499 created "2016-06-24" @default.
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- W989895499 date "2011-01-01" @default.
- W989895499 modified "2023-09-23" @default.
- W989895499 title "淫羊藿苷对基因转染PC12细胞α-突触核蛋白过表达和泛素-蛋白酶体系统的影响" @default.
- W989895499 hasPublicationYear "2011" @default.
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