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- W990086548 abstract "AIM: To dectect the effects of scopolamine on expression of phospho-cAMP response element binding protein (p-CREB) and c-Fos in amygdala nucleus (Amy) in rats with recurrence of conditioned place preference (CPP) induced by morphine. METHODS: Morphine was administered by subcutaneous injection at gradually increasing dose (from 10 mg/kg to 60 mg/kg) for 6 days to establish CPP model. From d 7, the rats were administered saline instead of morphine for 10 days to induce CPP extinction. The rats were given a single priming injection of morphine (4 mg/kg) to reinstate the CPP model, some rats were treated by i. p. scopolamine (1, 2, 3 mg/kg) prior to priminging injection of morphine. The expression of p-CREB and c-Fos in Amy were assayed by immunohistochemistry in the phase of reoccurrence of CPP. RESULTS: After priming injection of morphine 4 mg/kg, the time spent on the drug paired side was significantly reduced because of the treatment with scopolamine, compared with that in the morphine group(P＜0.05). Compared with the morphine group, scopolamine decreased the expression of p-CREB and c-Fos of Amy in rats (P＜0.05). CONCLUSION: The effects of scopolamine inhibiting morphine CPP reccurrence were probably related to its inhibitory effect on p-CREB and c-Fos expression of Amy in rat." @default.
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- W990086548 date "2008-01-26" @default.
- W990086548 modified "2023-09-23" @default.
- W990086548 title "东莨菪碱对吗啡诱发条件位置性偏爱重现大鼠杏仁核p-CREB及c-Fos表达的影响" @default.
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