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• W990124919 startingPage "727" @default.
• W990124919 abstract "Deterioration of motor function is a hallmark of senescence in humans and other mammalian species. The similarity of age-related motor deterioration to the symptoms of Parkinson's disease has focused research efforts upon the basal ganglia and particularly the nigrotriatal dopaminergic system. In this chapter, age-related structural and functional characteristics of basal ganglia of several laboratory animal species were reviewed. Although some studies have demonstrated loss of substantia nigra pars compacta dopaminergic neurons with age, the degree of loss does not appear sufficient to account for the marked motor decrements that occur in senescence. Consequently, studies of age-related changes in nigrostriatal function have increased. Reported changes in the basal ganglia of aged animals include decreased numbers of dopamine receptors and transporters as well as decreased dopamine synthesis, release, and uptake. There is also evidence for changes in the interactions between dopamine and other neurotransmitters in the basal ganglia. These age-related changes in nigrostriatal dopaminergic function may account for the majority of the motor deficits that accompany normal aging. © 2001 Academic Press." @default.
• W990124919 created "2016-06-24" @default.
• W990124919 creator A5003453711 @default.
• W990124919 creator A5037708891 @default.
• W990124919 creator A5041435529 @default.
• W990124919 date "2001-01-01" @default.
• W990124919 modified "2023-10-16" @default.
• W990124919 title "Biochemical and Anatomical Changes in Basal Ganglia of Aging Animals" @default.
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