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- W990228480 abstract "The present paper summarizes experimental evidence on the protection against brain hypoxia using calcium entry blockers in a variety of animal models. It appears that they are not a homogeneous class of pharmacological substances. This is partly due to the fact that the models used do not measure one particular causal factor related to hypoxia. The reasons for the final brain hypoxia are often multiple, originating from ischaemia (cardiovascular effects), respiratory problems, hypothermia, etc. However, the final outcome, independent of the original causes might be cellular toxicity by transmembrane calcium influx beyond physiological limits. Further studies are required to determine whether the protective action of calcium entry blockers resides primarily in their action on cerebral vessels and/or neurons. In view of the postulated role for calcium entry as the trigger of the events leading to cellular toxicity, it might be that calcium entry blockers will become important tools in preventing neuronal damage. Further emphasis will have to be given to physiologically controlled models of hypoxia and studies combining various techniques, including direct measures of ion fluxes through the membrane in order to achieve the final goal: brain protection." @default.
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- W990228480 date "1984-01-01" @default.
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- W990228480 title "Effect of calcium entry blockers in models of brain hypoxia" @default.
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- W990228480 doi "https://doi.org/10.1007/978-94-009-6033-6_22" @default.
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