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- W99043068 abstract "No AccessJournal of Urology1 Sep 1985Effect of Local Alpha-Adrenergic Blockade on Human Penile Erection Michael D. Blum, Robert R. Bahnson, Thomas N. Porter, and Michael F. Carter Michael D. BlumMichael D. Blum More articles by this author , Robert R. BahnsonRobert R. Bahnson More articles by this author , Thomas N. PorterThomas N. Porter More articles by this author , and Michael F. CarterMichael F. Carter More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)47248-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Recent data suggest that selective local blockade of the alpha-adrenergic receptors of the sympathetic innervation within the corpora cavernosa of the penis will result in erection in normal and impotent subjects. To examine this hypothesis we studied in a randomized, double-blinded fashion 8 impotent patients and 2 normal controls. The organic nature of the impotence was documented with nocturnal penile tumescence testing, sacral latency examination, Doppler penile blood flow measurements, hormonal evaluation and psychological testing. The 2 normal controls had full erections for 5 to 7 minutes after the intracorporeal injection of 5mg. phentolamine. All of the impotent subjects had tumescence without full erection after a similar injection. The tumescence was augmented by standing upright and diminished by assuming a supine posture, and lasted for several hours. Possible mechanisms, and diagnostic and therapeutic implications are discussed. © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byPARK J, KIM S, KIM S, KIM Y and CHO K (2018) RENIN ANGIOTENSIN SYSTEM OF RABBIT CLITORAL CAVERNOSUM: INTERACTION WITH NITRIC OXIDEJournal of Urology, VOL. 164, NO. 2, (556-561), Online publication date: 1-Aug-2000.Nunez B and Anderson D (2018) Nitroglycerin Ointment in the Treatment of ImpotenceJournal of Urology, VOL. 150, NO. 4, (1241-1243), Online publication date: 1-Oct-1993.Costa P, Sarrazin B, Bressolle F, Colson M, Bondil P and Saudubray F (2018) Efficiency and Side Effects of Intracavernous Injections of Moxisylyte in Impotent Patients: A Dose-Finding Study Versus PlaceboJournal of Urology, VOL. 149, NO. 2, (301-305), Online publication date: 1-Feb-1993.Lerner S, Melman A and Christ G (2018) A Review of Erectile Dysfunction: New Insights and More QuestionsJournal of Urology, VOL. 149, NO. 5 Part 2, (1246-1255), Online publication date: 1-May-1993.De Tejada I, Ware J, Blanco R, Pittard J, Nadig P, Azadzoi K, Krane R and Goldstein I (2018) Pathophysiology of Prolonged Penile Erection associated with Trazodone UseJournal of Urology, VOL. 145, NO. 1, (60-64), Online publication date: 1-Jan-1991.Mueller S, Aboseif S, Fahey M, Lue T and Tanagho E (2018) Spinal Anesthesia and Electroerection in Dogs and MonkeysJournal of Urology, VOL. 142, NO. 1, (171-175), Online publication date: 1-Jul-1989.Hadzija B, Mattocks A and Stahl G (2018) Physicochemical Stability of Papaverine Hydrochloride-Phentolamine Mesylate Mixtures Used for Intracavernous Injection: A Preliminary EvaluationJournal of Urology, VOL. 140, NO. 1, (64-65), Online publication date: 1-Jul-1988.Allen R and Brendler C (2018) Nocturnal Penile Tumescence Predicting Response to Intracorporeal Pharmacological Erection TestingJournal of Urology, VOL. 140, NO. 3, (518-522), Online publication date: 1-Sep-1988.Lue T (2018) Editorial CommentsJournal of Urology, VOL. 140, NO. 3, (522-522), Online publication date: 1-Sep-1988. (2018) Reply by AuthorsJournal of Urology, VOL. 140, NO. 3, (522-522), Online publication date: 1-Sep-1988.Shapiro E and Lepor H (2018) Alpha1, Adrenergic Receptors in Canine Lower Genitourinary Tissues: Insight into Development and FunctionJournal of Urology, VOL. 138, NO. 4 Part 2, (979-983), Online publication date: 1-Oct-1987. Volume 134Issue 3September 1985Page: 479-481 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Michael D. Blum More articles by this author Robert R. Bahnson More articles by this author Thomas N. Porter More articles by this author Michael F. Carter More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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- W99043068 title "Effect of Local Alpha-Adrenergic Blockade on Human Penile Erection" @default.
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