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- W99054387 abstract "Free radicals in the lipids extracted from the liver and spleen of irradiated rats by alcohol-ether were examined by the electron paramagnetic resonance method. The amount of free radicals in the preparations depended somewhat on the purity of the extractant, being highest when the reagent was distilled from SnCl/sub 2/--H/sub 2/SO/sub 4/. After a whole-body dose of 1000 r, the quantity of free radicals in the liver lipids 5 min after irradiation reached an average of 178% of that in the controls. This level was maintained to 24 hr, but at 48 hr reached 236%. Then, at 66 hr, it had dropped to 64%. The free radical content of the lipids from the spleen did not change after 5 min or 24 hr, but 48 hr after irradiation it had sharply increased. Data on synthesis of lipids show that the highest incorporation in lipids of tagged acetate occurs at 48 hr, and then there is a sharp drop in the rate of synthesis at three days. These results indicate a connection between lipid synthesis and free radical formation. The possibility is suggested that the substances detected here as free radicals are easily oxidized compounds which give up free electrons andmore » are then converted to free radicals. (TTT)« less" @default.
- W99054387 created "2016-06-24" @default.
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- W99054387 date "1963-01-01" @default.
- W99054387 modified "2023-09-23" @default.
- W99054387 title "FREE RADICALS IN LIPIDS OF THE LIVER AND SPLEEN OF IRRADIATED RATS" @default.
- W99054387 hasPublicationYear "1963" @default.
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