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- W990594404 abstract "This chapter discusses the role of Schistosoma in host-parasite pathological interactions. Schistosomes are able to synthesize a large variety of glycoproteins and glycolipids that specifically interact with the host. Throughout the various life-cycle stages, the parasite employs similar or identical carbohydrate epitopes on different proteins, probably to specifically evade the host defense mechanisms. The chapter presents examples, such as the presence of cross-reactive carbohydrate epitopes on egg and schistosomulum surface antigens that induce parasite-protective blocking antibodies, mimicry of host neutrophil surface carbohydrates to elicit antibodies that partly destroy this leucocyte subpopulation, and synthesis of highly negatively charged polysaccharides that probably inhibit cellular activation by Clq. In addition, the chapter discusses that deposition of schistosome circulating anodic antigen (CAA)-containing immune complexes in the glomeruli was involved in severe kidney pathology, and that a specific egg glycoprotein might be one of the causes of hepatotoxicity resulting from eggs." @default.
- W990594404 created "2016-06-24" @default.
- W990594404 creator A5032566952 @default.
- W990594404 creator A5039947825 @default.
- W990594404 date "1996-01-01" @default.
- W990594404 modified "2023-09-25" @default.
- W990594404 title "Chapter 2d Glycoproteins of parasites" @default.
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