Matches in SemOpenAlex for { <https://semopenalex.org/work/W990752912> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W990752912 abstract "Kutatasaink celja a rubeolavirus (RV), a vesicularis stomatitis virus (VSV) es a herpes simplex virus (HSV) sejtkarosito es teratogen hatasanak jobb megertese volt, ezert azt tanulmanyoztuk, hogy ezen virusok befolyasoljak-e a p63 es a Bcl-2 csaladba tarozo feherjek expressziojat. RV fertőzes hatasara, mindegyik TAp63 izoforma szintje emelkedett, mig a deltaNp63alfa szintje csokkent Vero sejtekben. VSV fertőzes hatasara, a Bcl-2 es a Bax-alfa szintje csokkent, a p53 es a p63 szintje nem valtozott, mig a p18 Bax expresszioja jelentős mertekben emelkedett WK sejtekben. VSV-vel fertőzott HaCaT sejtekben a deltaNp63alfa es a mutans p53 szintje csokkent, a Bcl-2 nem valtozott, mig a Bax-alfa es a p18 Bax expresszioja fokozodott. HSV fertőzes hatasara, a deltaNp63alfa szintje csokkent, mig nehany mas p63 izoforma expresszioja fokozodott. Tovabba, a HSV fertőzes a Bax-beta szintjenek emelkedeset valtotta ki. Eredmenyeink azt mutatjak, hogy mindharom virus befolyasolja a p63 izoformak es a Bcl-2 csaladtagok aranyat, de egymastol elterő modon. A kulonboző p63 izoformak szintjenek valtozasa fontos szerepet jatszhat ezen virusok sejtkarosito es teratogen hatasaban. | We have investigated the effects of rubella virus (RV), vesicular stomatitis virus and herpes simplex virus (HSV) on the expressions of p63 isoforms and Bcl-2 family members, in an effort to gain some insight into the cytopathic and teratogenic effects of these viruses. Our studies have shown that RV-infected Vero cells displayed highly elevated levels of each TAp63 isoform and a decreased level of deltaNp63alpha. The levels of Bcl-2 and Bax-alpha were decreased, p53 and p63 remained unaffected, while the expression of p18 Bax was increased in VSV-infected WK cells. The levels of deltaNp63alpha and mutated p53 were decreased, Bcl-2 remained unaffected, while the expressions of Bax-alpha and p18 Bax were increased in VSV-infected HaCaT cells. HSV-infected HaCaT cells exhibited decreased level of deltaNp63alpha and highly elevated levels of some other p63 isoforms. Moreover, HSV infection caused a significant increase in the expression level of Bax-beta. Taken together, our data demonstrate that RV, VSV and HSV infections alter the stoichiometric ratios of the p63 isoforms and Bcl-2 family members, but in different ways. The dysregulated patterns of p63 expression observed in the infected cells may represent mechanisms whereby these viruses exert their cytopathic and teratogenic effects." @default.
- W990752912 created "2016-06-24" @default.
- W990752912 creator A5010436599 @default.
- W990752912 creator A5048375546 @default.
- W990752912 creator A5060068446 @default.
- W990752912 creator A5087533323 @default.
- W990752912 date "2007-01-01" @default.
- W990752912 modified "2023-09-23" @default.
- W990752912 title "A p53 transzkripciós faktor család szerepe teratogén vírusok sejtkárosító hatásának molekuláris mechanizmusában = The role of the p53 transcription factor family in the molecular mechanism of cytopatic effect elicited by teratogenic viruses" @default.
- W990752912 hasPublicationYear "2007" @default.
- W990752912 type Work @default.
- W990752912 sameAs 990752912 @default.
- W990752912 citedByCount "0" @default.
- W990752912 crossrefType "journal-article" @default.
- W990752912 hasAuthorship W990752912A5010436599 @default.
- W990752912 hasAuthorship W990752912A5048375546 @default.
- W990752912 hasAuthorship W990752912A5060068446 @default.
- W990752912 hasAuthorship W990752912A5087533323 @default.
- W990752912 hasConcept C153911025 @default.
- W990752912 hasConcept C159047783 @default.
- W990752912 hasConcept C2522874641 @default.
- W990752912 hasConcept C2779057330 @default.
- W990752912 hasConcept C2781196997 @default.
- W990752912 hasConcept C2910348395 @default.
- W990752912 hasConcept C86803240 @default.
- W990752912 hasConcept C89138240 @default.
- W990752912 hasConceptScore W990752912C153911025 @default.
- W990752912 hasConceptScore W990752912C159047783 @default.
- W990752912 hasConceptScore W990752912C2522874641 @default.
- W990752912 hasConceptScore W990752912C2779057330 @default.
- W990752912 hasConceptScore W990752912C2781196997 @default.
- W990752912 hasConceptScore W990752912C2910348395 @default.
- W990752912 hasConceptScore W990752912C86803240 @default.
- W990752912 hasConceptScore W990752912C89138240 @default.
- W990752912 hasLocation W9907529121 @default.
- W990752912 hasOpenAccess W990752912 @default.
- W990752912 hasPrimaryLocation W9907529121 @default.
- W990752912 hasRelatedWork W2027092498 @default.
- W990752912 hasRelatedWork W2331160070 @default.
- W990752912 hasRelatedWork W3030627867 @default.
- W990752912 isParatext "false" @default.
- W990752912 isRetracted "false" @default.
- W990752912 magId "990752912" @default.
- W990752912 workType "article" @default.