Matches in SemOpenAlex for { <https://semopenalex.org/work/W991054534> ?p ?o ?g. }
- W991054534 endingPage "500" @default.
- W991054534 startingPage "486" @default.
- W991054534 abstract "Publisher Summary This chapter summarizes catalytic mechanism for cysteine peptidases of the papain family. Cysteine peptidases of the papain family catalyze the hydrolysis of peptide, amide, ester, thiol ester, and thiono ester bonds. The basic features of the mechanism include the formation of a covalent intermediate, the acyl-enzyme, resulting from nucleophilic attack of the active site thiol group on the carbonyl carbon of the scissile amide or ester bond of the bound substrate. The aspect of cysteine peptidases, which is of primary importance for their catalytic activity, is the high nucleophilicity of the active site thiol group. The existence of two ionizable groups as essential catalytic residues in papain is consistent with the bell-shape form for the pH dependency of activity with this enzyme. Papain has a large binding site and there are a number of interactions that exist between the enzyme and the substrate over an extended region. Coupling of these substrate binding interactions to the hydrolytic process occurring at the active site is an important aspect of catalysis." @default.
- W991054534 created "2016-06-24" @default.
- W991054534 creator A5011745491 @default.
- W991054534 creator A5090164097 @default.
- W991054534 date "1994-01-01" @default.
- W991054534 modified "2023-10-09" @default.
- W991054534 title "[33] Catalytic mechanism in papain family of cysteine peptidases" @default.
- W991054534 cites W114840063 @default.
- W991054534 cites W1512680533 @default.
- W991054534 cites W1513574545 @default.
- W991054534 cites W1553900867 @default.
- W991054534 cites W1578380009 @default.
- W991054534 cites W1638216569 @default.
- W991054534 cites W1693419395 @default.
- W991054534 cites W1813573266 @default.
- W991054534 cites W1834664979 @default.
- W991054534 cites W1845792010 @default.
- W991054534 cites W1966129178 @default.
- W991054534 cites W1966563251 @default.
- W991054534 cites W1967352806 @default.
- W991054534 cites W1967600844 @default.
- W991054534 cites W1968854847 @default.
- W991054534 cites W1969485280 @default.
- W991054534 cites W1973181401 @default.
- W991054534 cites W1974602191 @default.
- W991054534 cites W1978804937 @default.
- W991054534 cites W1980525207 @default.
- W991054534 cites W1986579209 @default.
- W991054534 cites W1990212536 @default.
- W991054534 cites W1994115481 @default.
- W991054534 cites W1995098028 @default.
- W991054534 cites W1999398927 @default.
- W991054534 cites W2000388754 @default.
- W991054534 cites W2007124265 @default.
- W991054534 cites W2007230183 @default.
- W991054534 cites W2010597910 @default.
- W991054534 cites W2011875568 @default.
- W991054534 cites W2016369925 @default.
- W991054534 cites W2021996491 @default.
- W991054534 cites W2024531915 @default.
- W991054534 cites W2031078729 @default.
- W991054534 cites W2035953115 @default.
- W991054534 cites W2041603274 @default.
- W991054534 cites W2042990275 @default.
- W991054534 cites W2046422911 @default.
- W991054534 cites W2057935487 @default.
- W991054534 cites W2060087859 @default.
- W991054534 cites W2065862200 @default.
- W991054534 cites W2071010993 @default.
- W991054534 cites W2072410647 @default.
- W991054534 cites W2077470057 @default.
- W991054534 cites W2082101541 @default.
- W991054534 cites W2083622267 @default.
- W991054534 cites W2089153412 @default.
- W991054534 cites W2097086424 @default.
- W991054534 cites W2111202640 @default.
- W991054534 cites W213276481 @default.
- W991054534 cites W2150951870 @default.
- W991054534 cites W2155158416 @default.
- W991054534 cites W2171797887 @default.
- W991054534 cites W2246185977 @default.
- W991054534 cites W2250613068 @default.
- W991054534 cites W2267629330 @default.
- W991054534 cites W2272494251 @default.
- W991054534 cites W2274217909 @default.
- W991054534 cites W2329451853 @default.
- W991054534 cites W2337865112 @default.
- W991054534 cites W2339487834 @default.
- W991054534 cites W2344317983 @default.
- W991054534 cites W2412553964 @default.
- W991054534 cites W2418128102 @default.
- W991054534 cites W2418237316 @default.
- W991054534 cites W2949591870 @default.
- W991054534 doi "https://doi.org/10.1016/0076-6879(94)44035-2" @default.
- W991054534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7845227" @default.
- W991054534 hasPublicationYear "1994" @default.
- W991054534 type Work @default.
- W991054534 sameAs 991054534 @default.
- W991054534 citedByCount "236" @default.
- W991054534 countsByYear W9910545342012 @default.
- W991054534 countsByYear W9910545342013 @default.
- W991054534 countsByYear W9910545342014 @default.
- W991054534 countsByYear W9910545342015 @default.
- W991054534 countsByYear W9910545342016 @default.
- W991054534 countsByYear W9910545342017 @default.
- W991054534 countsByYear W9910545342018 @default.
- W991054534 countsByYear W9910545342019 @default.
- W991054534 countsByYear W9910545342020 @default.
- W991054534 countsByYear W9910545342021 @default.
- W991054534 countsByYear W9910545342022 @default.
- W991054534 countsByYear W9910545342023 @default.
- W991054534 crossrefType "book-chapter" @default.
- W991054534 hasAuthorship W991054534A5011745491 @default.
- W991054534 hasAuthorship W991054534A5090164097 @default.
- W991054534 hasConcept C111472728 @default.
- W991054534 hasConcept C138885662 @default.
- W991054534 hasConcept C161790260 @default.
- W991054534 hasConcept C181199279 @default.