FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W991071337> ?p ?o ?g. }

• W991071337 endingPage "1449" @default.
• W991071337 startingPage "1441" @default.
• W991071337 abstract "Type 2 diabetes mellitus (T2DM) is associated with dementia. Mild cognitive impairment (MCI) is a key determinant in this association. It is not clear whether T2DM increases the risk of conversion from MCI to dementia. We plan to explore the relationship between T2DM-MCI and dementia and identify its potential risk factors. A prospective community-based cohort study was conducted from March 2010 to March 2014, including 634 participants with T2DM-MCI, 261 T2DM participants who were cognitively intact, and 585 MCI participants without diabetes. All cohort members received detailed annual evaluations to detect dementia onset during the 5 years of follow-up. The three cohorts were compared to assess differences in dementia onset. Furthermore, Cox proportional hazards regression was used to identify risk factors for dementia onset in the T2DM-MCI cohort. During follow-up, 152 and 49 subjects developed dementia in the MCI and cognitively-intact cohorts, amounting to an adjusted hazard ratio (HR) of 1.66 (95% CI 1.07-2.26). In a survival analysis of the cohorts, MCI accelerated the median progression to dementia by 2.74 years. In a multivariable analysis of the T2DM-MCI cohort, major risk factors for dementia were age >75 years and longer durations of diabetes, while significantly reduced risks of dementia were associated with oral hypoglycemic agents and HMG-CoA reductase inhibitors. Insulin was not associated with significantly changed risk. T2DM-MCI may aggravate the clinical picture as a concomitant factor. To minimize progression to dementia, it may be worthwhile to target several modifiable diabetes-specific features, such as the duration of disease, glycemic control, and antidiabetic agents." @default.
• W991071337 created "2016-06-24" @default.
• W991071337 creator A5001431706 @default.
• W991071337 creator A5044484963 @default.
• W991071337 creator A5047069366 @default.
• W991071337 creator A5052588320 @default.
• W991071337 creator A5056321054 @default.
• W991071337 creator A5072736924 @default.
• W991071337 date "2014-12-23" @default.
• W991071337 modified "2023-09-23" @default.
• W991071337 title "Conversion of Mild Cognitive Impairment to Dementia among Subjects with Diabetes: A Population-Based Study of Incidence and Risk Factors with Five Years of Follow-up" @default.
• W991071337 cites W1971310460 @default.
• W991071337 cites W2003106438 @default.
• W991071337 cites W2005481412 @default.
• W991071337 cites W2017474477 @default.
• W991071337 cites W2020267609 @default.
• W991071337 cites W2020389344 @default.
• W991071337 cites W2036021750 @default.
• W991071337 cites W2036538757 @default.
• W991071337 cites W2042547780 @default.
• W991071337 cites W2057042201 @default.
• W991071337 cites W2057213039 @default.
• W991071337 cites W2068690756 @default.
• W991071337 cites W2074249519 @default.
• W991071337 cites W2088642279 @default.
• W991071337 cites W2101048381 @default.
• W991071337 cites W2107209365 @default.
• W991071337 cites W2113540488 @default.
• W991071337 cites W2117176621 @default.
• W991071337 cites W2122485874 @default.
• W991071337 cites W2129769880 @default.
• W991071337 cites W2156220037 @default.
• W991071337 cites W2157665412 @default.
• W991071337 cites W2158308909 @default.
• W991071337 cites W2159122349 @default.
• W991071337 cites W2209976199 @default.
• W991071337 doi "https://doi.org/10.3233/jad-141566" @default.
• W991071337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25159674" @default.
• W991071337 hasPublicationYear "2014" @default.
• W991071337 type Work @default.
• W991071337 sameAs 991071337 @default.
• W991071337 citedByCount "66" @default.
• W991071337 countsByYear W9910713372014 @default.
• W991071337 countsByYear W9910713372015 @default.
• W991071337 countsByYear W9910713372016 @default.
• W991071337 countsByYear W9910713372017 @default.
• W991071337 countsByYear W9910713372018 @default.
• W991071337 countsByYear W9910713372019 @default.
• W991071337 countsByYear W9910713372020 @default.
• W991071337 countsByYear W9910713372021 @default.
• W991071337 countsByYear W9910713372022 @default.
• W991071337 countsByYear W9910713372023 @default.
• W991071337 crossrefType "journal-article" @default.
• W991071337 hasAuthorship W991071337A5001431706 @default.
• W991071337 hasAuthorship W991071337A5044484963 @default.
• W991071337 hasAuthorship W991071337A5047069366 @default.
• W991071337 hasAuthorship W991071337A5052588320 @default.
• W991071337 hasAuthorship W991071337A5056321054 @default.
• W991071337 hasAuthorship W991071337A5072736924 @default.
• W991071337 hasConcept C126322002 @default.
• W991071337 hasConcept C134018914 @default.
• W991071337 hasConcept C188816634 @default.
• W991071337 hasConcept C201903717 @default.
• W991071337 hasConcept C207103383 @default.
• W991071337 hasConcept C2779134260 @default.
• W991071337 hasConcept C2779483572 @default.
• W991071337 hasConcept C2908647359 @default.
• W991071337 hasConcept C44249647 @default.
• W991071337 hasConcept C50382708 @default.
• W991071337 hasConcept C50440223 @default.
• W991071337 hasConcept C555293320 @default.
• W991071337 hasConcept C71924100 @default.
• W991071337 hasConcept C72563966 @default.
• W991071337 hasConcept C74909509 @default.
• W991071337 hasConcept C99454951 @default.
• W991071337 hasConceptScore W991071337C126322002 @default.
• W991071337 hasConceptScore W991071337C134018914 @default.
• W991071337 hasConceptScore W991071337C188816634 @default.
• W991071337 hasConceptScore W991071337C201903717 @default.
• W991071337 hasConceptScore W991071337C207103383 @default.
• W991071337 hasConceptScore W991071337C2779134260 @default.
• W991071337 hasConceptScore W991071337C2779483572 @default.
• W991071337 hasConceptScore W991071337C2908647359 @default.
• W991071337 hasConceptScore W991071337C44249647 @default.
• W991071337 hasConceptScore W991071337C50382708 @default.
• W991071337 hasConceptScore W991071337C50440223 @default.
• W991071337 hasConceptScore W991071337C555293320 @default.
• W991071337 hasConceptScore W991071337C71924100 @default.
• W991071337 hasConceptScore W991071337C72563966 @default.
• W991071337 hasConceptScore W991071337C74909509 @default.
• W991071337 hasConceptScore W991071337C99454951 @default.
• W991071337 hasIssue "4" @default.
• W991071337 hasLocation W9910713371 @default.
• W991071337 hasLocation W9910713372 @default.
• W991071337 hasOpenAccess W991071337 @default.
• W991071337 hasPrimaryLocation W9910713371 @default.
• W991071337 hasRelatedWork W1999097079 @default.
• W991071337 hasRelatedWork W2115381884 @default.

• next