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• W991210025 abstract "Bacterial whole genome sequencing holds promise as a disruptive technology in clinical microbiology, but it has not yet been applied systematically or comprehensively within a clinical context. Here, over the course of one year, we performed prospective collection and whole genome sequencing of nearly all bacterial isolates obtained from a tertiary care hospital's intensive care units (ICUs). This unbiased collection of 1,229 bacterial genomes from 391 patients enables detailed exploration of several features of clinical pathogens. A sizable fraction of isolates identified as clinically relevant corresponded to previously undescribed species: 12% of isolates assigned a species-level classification by conventional methods actually qualified as distinct, novel genomospecies on the basis of genomic similarity. Pan-genome analysis of the most frequently encountered pathogens in the collection revealed substantial variation in pan-genome size (1,420 to 20,432 genes) and the rate of gene discovery (1 to 152 genes per isolate sequenced). Surprisingly, although potential nosocomial transmission of actively surveilled pathogens was rare, 8.7% of isolates belonged to genomically related clonal lineages that were present among multiple patients, usually with overlapping hospital admissions, and were associated with clinically significant infection in 62% of patients from which they were recovered. Multi-patient clonal lineages were particularly evident in the neonatal care unit, where seven separate Staphylococcus epidermidis clonal lineages were identified, including one lineage associated with bacteremia in 5/9 neonates. Our study highlights key differences in the information made available by conventional microbiological practices versus whole genome sequencing, and motivates the further integration of microbial genome sequencing into routine clinical care." @default.
• W991210025 created "2016-06-24" @default.
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• W991210025 date "2015-07-31" @default.
• W991210025 modified "2023-10-10" @default.
• W991210025 title "A Year of Infection in the Intensive Care Unit: Prospective Whole Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic Transmissions and Novel Microbiota" @default.
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• W991210025 cites W1966822396 @default.
• W991210025 cites W1976718759 @default.
• W991210025 cites W1980030331 @default.
• W991210025 cites W1989349313 @default.
• W991210025 cites W1991053265 @default.
• W991210025 cites W2004548026 @default.
• W991210025 cites W2018782288 @default.
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• W991210025 cites W2034677156 @default.
• W991210025 cites W2034990238 @default.
• W991210025 cites W2038468341 @default.
• W991210025 cites W2038699241 @default.
• W991210025 cites W2041127220 @default.
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• W991210025 doi "https://doi.org/10.1371/journal.pgen.1005413" @default.
• W991210025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5391911" @default.
• W991210025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28410416" @default.
• W991210025 hasPublicationYear "2015" @default.
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