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• W991269750 abstract "This chapter reports a study of the effect of colchicines on the synthesis and secretion of albumin, which proves useful in determining at which steps of hepatic secretion colchicine exerts its inhibitory action and which leads to a further understanding of the molecular mechanisms that govern the secretory steps affected by colchicines. Rat albumin is synthesized on polysomes attached to the endoplasmic reticulum (ER) membrane, is vectorially discharged into the lumen of the rough ER, and then is transported stepwise to the smooth ER, to the Golgi complex, and to secretory vesicles that fuse with the plasma membrane and secrete albumin into the space of Disse. Colchicine given intravenously to a rat can cause inhibition of plasma protein secretion and an accumulation of the nonsecreted proteins within the liver. At these doses, the inhibitory effect of colchicine is prompt and noticed within 2 minutes of colchicine administration. Colchicine is a general inhibitor of in vivo secretion, as it inhibits the secretion of albumin, and that of other plasma proteins produced by the liver." @default.
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• W991269750 date "1981-01-01" @default.
• W991269750 modified "2023-09-27" @default.
• W991269750 title "Chapter 15 The Effect of Colchicine on the Synthesis and Secretion of Rat Serum Albumin" @default.
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• W991269750 doi "https://doi.org/10.1016/s0091-679x(08)61501-0" @default.
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