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- W9913207 abstract "This chapter summarizes the major findings that are significant in understanding the clonal development and progression of human hemopoietic neoplasia. Determination of whether a cellular proliferation is monoclonal or polyclonal has important pathogenetic implications. Polyclonal proliferations are often the result of normal processes in which a tissue responds appropriately to an exogenous stimulus. On the other hand, monoclonal proliferations reflect disordered hemopoiesis in which a clone of cells gains in vivo proliferative advantage. The ability to detect monoclonality in proliferating cells requires a marker system that enables the progeny of different cells to be recognized. Markers that are used effectively to investigate human lymphoid neoplasia include immunoglobulin (Ig) proteins synthesized by relatively mature cells of B-lymphoid origin, DNA sequences coding for these Igs, and T-cell receptor gene rearrangements. Beyond determining whether a disease state is clonal at the time of presentation, studies with cell markers allow characterization of the clonal state throughout subsequent stages of the disease and the differentiative expression of the stem cell involved by the clonal proliferation. Many human hemopoietic neoplasias appear to have a multistep pathogenesis. The diploid cell may represent an early stage in leukemogenesis. Subsequent development of structural chromosomal alterations or aneuploidies may lead to frank leukemia by any of a number of mechanisms, such as activation of an oncogene, amplification of a gene whose product is important for growth, or loss of a gene involved in repressing or regulating growth. The malignant phenotype then progresses by stepwise evolution." @default.
- W9913207 created "2016-06-24" @default.
- W9913207 creator A5038111213 @default.
- W9913207 creator A5090263115 @default.
- W9913207 date "1987-01-01" @default.
- W9913207 modified "2023-09-26" @default.
- W9913207 title "The Use of Cell Markers in The Study of Human Hematopoietic Neoplasia" @default.
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