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- W991619046 abstract "The antihypertensive action of spironolactone has been ascribed to both a nonspecific diuretic and an antimineralocorticoid effect. By inhibiting the action of aldosterone in the distal nephron, spironolactone blocks the reabsorption of Na+ ions by the luminal membrane in the cortical collecting ducts. This is the basis of its natriuretic and diuretic efficiency. Through this salt and water excretory capacity, spironolactone leads to volume depletion and, thereby, to a lowering of the blood pressure. When high blood pressure is caused by overproduction of mineralocorticoids, such as aldosterone, the blood-pressure-lowering effect of spironolactone is considerable. In fact earlier, we, as well as others, reported that the lowering of blood pressure by spironolactone even in essential hypertension is greater the more aldosterone is secreted [1, 2]." @default.
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- W991619046 date "1983-01-01" @default.
- W991619046 modified "2023-09-27" @default.
- W991619046 title "Spironolactone in Essential Hypertension: Effects on Kidney Function and Plasma Electrolytes in Relation to Salt Intake" @default.
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- W991619046 doi "https://doi.org/10.1007/978-3-642-69081-5_18" @default.
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