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- W991630452 abstract "Publisher Summary This chapter describes the androgen metabolism in patients with benign prostatic hypertrophy. Methodological progress that enabled precise and sensitive measurement of androgens in various biological tissues has revealed that the process of aging has a considerable impact on androgen production, androgen binding in blood, and androgen metabolism. Testosterone excretion in urine exhibits a clear-cut age dependency. Highest values are observed between ages 25 and 30, after which a continuous decrease of the mean values is seen until the seventh age decade, thereafter the excretion remaining practically unaltered. It is found that while androgen concentrations in biological fluids decrease with advancing age a reverse tendency are found regarding estrogens, leading in consequence to an elevated estrogen. In vivo administration yielded a substantial conversion of androstenedione and a small conversion of dehydroepiandrosterone (DHEA) sulfate to 5α-DHT. Whereas the overall metabolism of DHEA sulfate was very low, androstenedione was converted mainly to epiandrosterone and to androsterone. The metabolite pattern obtained from prostatic tissue under in vitro conditions differed markedly from that found in vivo . The gestagens belong to the group of compounds which cause, also under in vivo conditions, a potent inhibition of 5α-reductase activity, resulting in a delayed testosterone metabolism." @default.
- W991630452 created "2016-06-24" @default.
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- W991630452 date "1976-01-01" @default.
- W991630452 modified "2023-10-16" @default.
- W991630452 title "Androgen Metabolism in Patients with Benign Prostatic Hypertrophy" @default.
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- W991630452 doi "https://doi.org/10.1016/s0083-6729(08)60968-1" @default.
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