Matches in SemOpenAlex for { <https://semopenalex.org/work/W991630669> ?p ?o ?g. }
- W991630669 endingPage "306" @default.
- W991630669 startingPage "4296" @default.
- W991630669 abstract "In this study, we aim to evaluate the connexin (Cx43) and phosphorylation Cx43 (p-Cx43) expression of human glioma tumors and correlate their expression with degrees of malignancy and proliferation, apoptosis, and migration activity of tumors. Cx43 and p-Cx43 expression were examined by Western blot analysis and immunohistochemical staining. The U251 cell viability was measured by MTT analysis. The apoptosis and migration were also evaluated by flow cytometric analysis and fluoroblok transwell chambers, respectively. We found that the Cx43 expression were significantly downregulated in in malignant glioma (WHO grade III and IV), compared to the malignant glioma (WHO grade I and II) and the p-Cx43 expression levels of malignant glioma (WHO grade III and IV) were significantly increased (P<0.05), compared to the malignant glioma (WHO grade I and II) at immunohistochemical analysis. After treatment of cells with a specific inhibitor of PKC, MAPK, and PTK inhibitors, the cell viability and migration were significantly decreased, while the apoptosis was slightly induced. In conclusion, the Cx43 expression level is inversely correlated with the tumor grade and proliferation and migration activity of tumor. Higher p-Cx43 expression level in high tumor grade suggests that a complex mechanism is involved in the suppression of tumor growth by connexins." @default.
- W991630669 created "2016-06-24" @default.
- W991630669 creator A5009575848 @default.
- W991630669 creator A5018241330 @default.
- W991630669 creator A5028673475 @default.
- W991630669 creator A5029563117 @default.
- W991630669 creator A5045309022 @default.
- W991630669 creator A5046147086 @default.
- W991630669 creator A5068158624 @default.
- W991630669 creator A5090239694 @default.
- W991630669 date "2015-01-01" @default.
- W991630669 modified "2023-09-25" @default.
- W991630669 title "Altered expression of connexin43 and phosphorylation connexin43 in glioma tumors." @default.
- W991630669 cites W1969875009 @default.
- W991630669 cites W1971685348 @default.
- W991630669 cites W1971739033 @default.
- W991630669 cites W1974726237 @default.
- W991630669 cites W1976142920 @default.
- W991630669 cites W1981940030 @default.
- W991630669 cites W1988849665 @default.
- W991630669 cites W1994578950 @default.
- W991630669 cites W2019015469 @default.
- W991630669 cites W2026761520 @default.
- W991630669 cites W2038824044 @default.
- W991630669 cites W2056590743 @default.
- W991630669 cites W2057226590 @default.
- W991630669 cites W2064467597 @default.
- W991630669 cites W2069466450 @default.
- W991630669 cites W2075388761 @default.
- W991630669 cites W2076459084 @default.
- W991630669 cites W2081876235 @default.
- W991630669 cites W2083730160 @default.
- W991630669 cites W2096287682 @default.
- W991630669 cites W2104838758 @default.
- W991630669 cites W2108088025 @default.
- W991630669 cites W2119624274 @default.
- W991630669 cites W2125951597 @default.
- W991630669 cites W2131101712 @default.
- W991630669 cites W2132384646 @default.
- W991630669 cites W2135499880 @default.
- W991630669 cites W2141752309 @default.
- W991630669 cites W2147346646 @default.
- W991630669 cites W2151794458 @default.
- W991630669 cites W2161930006 @default.
- W991630669 cites W2168866223 @default.
- W991630669 cites W2170309415 @default.
- W991630669 cites W2171409673 @default.
- W991630669 cites W2171457920 @default.
- W991630669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4502994" @default.
- W991630669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26191122" @default.
- W991630669 hasPublicationYear "2015" @default.
- W991630669 type Work @default.
- W991630669 sameAs 991630669 @default.
- W991630669 citedByCount "7" @default.
- W991630669 countsByYear W9916306692017 @default.
- W991630669 countsByYear W9916306692018 @default.
- W991630669 countsByYear W9916306692019 @default.
- W991630669 countsByYear W9916306692020 @default.
- W991630669 countsByYear W9916306692022 @default.
- W991630669 countsByYear W9916306692023 @default.
- W991630669 crossrefType "journal-article" @default.
- W991630669 hasAuthorship W991630669A5009575848 @default.
- W991630669 hasAuthorship W991630669A5018241330 @default.
- W991630669 hasAuthorship W991630669A5028673475 @default.
- W991630669 hasAuthorship W991630669A5029563117 @default.
- W991630669 hasAuthorship W991630669A5045309022 @default.
- W991630669 hasAuthorship W991630669A5046147086 @default.
- W991630669 hasAuthorship W991630669A5068158624 @default.
- W991630669 hasAuthorship W991630669A5090239694 @default.
- W991630669 hasConcept C104317684 @default.
- W991630669 hasConcept C142724271 @default.
- W991630669 hasConcept C153911025 @default.
- W991630669 hasConcept C158157758 @default.
- W991630669 hasConcept C190283241 @default.
- W991630669 hasConcept C204232928 @default.
- W991630669 hasConcept C2776415932 @default.
- W991630669 hasConcept C2778227246 @default.
- W991630669 hasConcept C2780228694 @default.
- W991630669 hasConcept C2780783641 @default.
- W991630669 hasConcept C502942594 @default.
- W991630669 hasConcept C53227056 @default.
- W991630669 hasConcept C54355233 @default.
- W991630669 hasConcept C553184892 @default.
- W991630669 hasConcept C55493867 @default.
- W991630669 hasConcept C62112901 @default.
- W991630669 hasConcept C71924100 @default.
- W991630669 hasConcept C79879829 @default.
- W991630669 hasConcept C86803240 @default.
- W991630669 hasConcept C95444343 @default.
- W991630669 hasConceptScore W991630669C104317684 @default.
- W991630669 hasConceptScore W991630669C142724271 @default.
- W991630669 hasConceptScore W991630669C153911025 @default.
- W991630669 hasConceptScore W991630669C158157758 @default.
- W991630669 hasConceptScore W991630669C190283241 @default.
- W991630669 hasConceptScore W991630669C204232928 @default.
- W991630669 hasConceptScore W991630669C2776415932 @default.
- W991630669 hasConceptScore W991630669C2778227246 @default.
- W991630669 hasConceptScore W991630669C2780228694 @default.