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- W991683603 abstract "Over the last decades, advances in the knowledge of immunology have led to the identification of immune checkpoints, reinvigorating cancer immunotherapy. Although normally restricted to activated T and B cells, constitutive expression of CD70 in tumor cells has been described. Moreover, CD70 is implicated in tumor cell and regulatory T cell survival through interaction with its ligand, CD27. In this review, we summarize the targetable expression patterns of CD70 in a wide range of malignancies and the promising mechanism of anti-CD70 therapy in stimulating the anti-tumor immune response. In addition, we will discuss clinical data and future combination strategies." @default.
- W991683603 created "2016-06-24" @default.
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- W991683603 creator A5056727791 @default.
- W991683603 creator A5069580321 @default.
- W991683603 creator A5074506844 @default.
- W991683603 date "2015-11-01" @default.
- W991683603 modified "2023-10-18" @default.
- W991683603 title "CD70: An emerging target in cancer immunotherapy" @default.
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