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- W99176723 abstract "This chapter will review specific applications of microarray technology and related data analysis strategies in antibacterial research and development. We present examples of microarray applications spanning the entire antibiotics research and development pipeline, from target discovery, assay development, pharmacological evaluation, to compound safety studies. This review emphasizes the utility of microarrays for a systematic evaluation of novel chemistry as antibiotic agents. Transcriptional profiling has revolutionized the process of target elucidation and has the potential to offer substantial guidance in the identification of new targets. Microarrays will continue to be a workhorse of anti-infectives discovery programs ranging from efficacy assessments of antibiotics ('forward pharmacology') to drug safety evaluations ('toxicogenomics')." @default.
- W99176723 created "2016-06-24" @default.
- W99176723 creator A5021310091 @default.
- W99176723 creator A5050250538 @default.
- W99176723 date "2007-01-01" @default.
- W99176723 modified "2023-09-26" @default.
- W99176723 title "Applications of transcriptional profiling in antibiotics discovery and development" @default.
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- W99176723 doi "https://doi.org/10.1007/978-3-7643-7567-6_2" @default.
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