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- W99177573 abstract "Nasopharyngeal carcinoma (NPC) is a rare disease in children with distinct epidemiological and etiological features, histopathological characteristics, and clinical presentation. The incidence of pediatric NPC varies widely around the world, and both genetic and environmental factors contribute to the development of the disease. Children with NPC almost always have the undifferentiated variant of the disease, which is associated with advanced locoregional spread and distant metastases. Currently, cisplatin-based induction chemotherapy followed by high-dose radiotherapy is the treatment of choice. Although multimodality treatment has increased the 5-year survival to 70%–90%, late morbidity is a major concern. Immune-modulation with interferon has resulted in excellent outcome, and studies have been extended to investigate the impact of immunotherapy on survival, in combination with less toxic chemoradiotherapy." @default.
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- W99177573 date "2010-01-01" @default.
- W99177573 modified "2023-09-25" @default.
- W99177573 title "Nasopharyngeal Cancer in Pediatric and Adolescent Patients" @default.
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- W99177573 doi "https://doi.org/10.1007/978-3-540-92810-2_23" @default.
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