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- W99180592 abstract "This chapter describes the development of rinderpest vaccines and the history of their use within the on-going, global assault on rinderpest. Having defined rinderpest as an entity, the first half of the history of man's acquaintance with this ruinous condition was devoted to attempts to cure sick animals. Drawing on the discovery in Russia that serum taken from a recovered animal had protective powers, the second half as it were begins with the final realization that the disease could be in fact be cured by the use of immune serum or repulsed by inducing a protective immunity in uninfected animals. The subsequent development of rinderpest vaccines paved the way for numerous attempts to modify the epidemiology of the virus by creating livestock populations so heavily immune that they could no longer support the presence of the virus. In the 1920s a number of workers succeeded in immunizing cattle with inactivated preparations of infected bovine tissues using toluol, eucalyptol, formalin, or chloroform. The history of goat vaccine, the first of several live attenuated rinderpest vaccines, is divided between India and Africa. With the advent of cell-culture techniques cattle's are satisfactorily immunized simultaneously with both rinderpest and anthrax/blackquarter vaccines provided that the tissue culture rinderpest vaccine and bacterial preparations were separately reconstituted." @default.
- W99180592 created "2016-06-24" @default.
- W99180592 creator A5054322180 @default.
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- W99180592 date "2006-01-01" @default.
- W99180592 modified "2023-10-14" @default.
- W99180592 title "History of vaccines and vaccination" @default.
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- W99180592 doi "https://doi.org/10.1016/b978-012088385-1/50041-1" @default.
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