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- W99180885 abstract "This chapter presents details of the workshop focusing on immune capabilities of germ-free animals. It highlights that germ-free animals are improved experimental subjects for studies on host-environment interactions. The most frequently used current species for immunological studies were mice, rats, guinea pigs, rabbits, and pigs. They were derived from full-term mothers by aseptic caesarian delivery directly into a sterile enclosure (isolator) in which they were maintained, propagated, and used under controlled conditions as regards to microbial flora, diet, temperature, humidity, light, and noise. They were free of horizontally-transmitted microbes and thereby manifested a low profile of activity in the lymphoreticular system. That is, except for the thymus, the immunological system, in general, was small and relatively inactive but functionally intact. The lymph nodes, spleen, and Peyer's patches contained small cortical follicles, few plasma cells, and low levels of serum globulins. Following exposures to antigenic stimuli, they became hyperplastic, germinal zones and plasma cells appear in them, and serum globulins were elevated." @default.
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- W99180885 date "1971-01-01" @default.
- W99180885 modified "2023-09-26" @default.
- W99180885 title "Immune Capabilities of Germ-Free Animals" @default.
- W99180885 doi "https://doi.org/10.1016/b978-0-12-057550-3.50118-6" @default.
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