Matches in SemOpenAlex for { <https://semopenalex.org/work/W99183872> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W99183872 endingPage "13" @default.
- W99183872 startingPage "7" @default.
- W99183872 abstract "Annually about 50,000 patients are hospitalized for acute stroke in Hungary. Of all stroke cases 85% are ischemic, and 15% are hemorrhagic (intracerebral or subarachnoid). In acute ischemic stroke the only registered causal treatment with proven efficacy is thrombolysis with intravenous administration of recombinant tissue plasminogen activator with a 3-hour time window. The indication areas of intraarterial thrombolysis are currently being established for selected cases in selected centers. Other studies examine the options to extend the time window and to test new thrombolytic agents. Despite the large number of studies none of the neuroprotectant agents have been found beneficial in randomized controlled clinical trials in acute stroke. According to the results of studies to date anticoagulant therapy (heparin) cannot be recommended for the routine treatment of acute stroke. Aspirin may be safely administered within 48 hours of ischemic stroke and results in a 1% decrease of death or disability at 6 months after stroke. There were no large studies on the use of other antiplatelet agents in acute stroke. If thrombolysis is performed, antiplatelet or anticoagulant agents should not be administered in the first 24 hours. Further studies are needed to test the efficacy and safety of anticoagulants in special cases of stroke (e.g. crescendo TIA-s, progressing stroke), and to test combined antiplatelet treatment in the acute phase of stroke. In acute intracerebral hemorrhage the beneficial effect of recombinant coagulation factor VII found in a small study could not be proved in a large phase III trial. Currently there is no evidence based pharmacotherapy for the specific treatment of intracerebral hemorrhage. In subarachnoid hemorrhage nimodipine was found effective in preventing vasospasm and thus secondary ischemic cerebral damage. Although the results of individual trials are conflicting, a systematic review on the effects of statins suggests a similar effect. Due to the limited options of evidence based treatments of acute stroke primary prevention has utmost importance." @default.
- W99183872 created "2016-06-24" @default.
- W99183872 creator A5090331551 @default.
- W99183872 date "2009-03-01" @default.
- W99183872 modified "2023-10-02" @default.
- W99183872 title "[Pharmacotherapy of stroke]." @default.
- W99183872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19731813" @default.
- W99183872 hasPublicationYear "2009" @default.
- W99183872 type Work @default.
- W99183872 sameAs 99183872 @default.
- W99183872 citedByCount "1" @default.
- W99183872 countsByYear W991838722018 @default.
- W99183872 crossrefType "journal-article" @default.
- W99183872 hasAuthorship W99183872A5090331551 @default.
- W99183872 hasConcept C126322002 @default.
- W99183872 hasConcept C127413603 @default.
- W99183872 hasConcept C177713679 @default.
- W99183872 hasConcept C2776572282 @default.
- W99183872 hasConcept C2777094939 @default.
- W99183872 hasConcept C2777628954 @default.
- W99183872 hasConcept C2777736543 @default.
- W99183872 hasConcept C2779581417 @default.
- W99183872 hasConcept C2780645631 @default.
- W99183872 hasConcept C2909817843 @default.
- W99183872 hasConcept C3020166492 @default.
- W99183872 hasConcept C500558357 @default.
- W99183872 hasConcept C535046627 @default.
- W99183872 hasConcept C71924100 @default.
- W99183872 hasConcept C78519656 @default.
- W99183872 hasConceptScore W99183872C126322002 @default.
- W99183872 hasConceptScore W99183872C127413603 @default.
- W99183872 hasConceptScore W99183872C177713679 @default.
- W99183872 hasConceptScore W99183872C2776572282 @default.
- W99183872 hasConceptScore W99183872C2777094939 @default.
- W99183872 hasConceptScore W99183872C2777628954 @default.
- W99183872 hasConceptScore W99183872C2777736543 @default.
- W99183872 hasConceptScore W99183872C2779581417 @default.
- W99183872 hasConceptScore W99183872C2780645631 @default.
- W99183872 hasConceptScore W99183872C2909817843 @default.
- W99183872 hasConceptScore W99183872C3020166492 @default.
- W99183872 hasConceptScore W99183872C500558357 @default.
- W99183872 hasConceptScore W99183872C535046627 @default.
- W99183872 hasConceptScore W99183872C71924100 @default.
- W99183872 hasConceptScore W99183872C78519656 @default.
- W99183872 hasIssue "1" @default.
- W99183872 hasLocation W991838721 @default.
- W99183872 hasOpenAccess W99183872 @default.
- W99183872 hasPrimaryLocation W991838721 @default.
- W99183872 hasRelatedWork W2020022111 @default.
- W99183872 hasRelatedWork W2035322701 @default.
- W99183872 hasRelatedWork W2088865135 @default.
- W99183872 hasRelatedWork W2310297169 @default.
- W99183872 hasRelatedWork W2418866215 @default.
- W99183872 hasRelatedWork W2758549448 @default.
- W99183872 hasRelatedWork W4206246422 @default.
- W99183872 hasRelatedWork W4206837619 @default.
- W99183872 hasRelatedWork W4231533453 @default.
- W99183872 hasRelatedWork W99183872 @default.
- W99183872 hasVolume "11" @default.
- W99183872 isParatext "false" @default.
- W99183872 isRetracted "false" @default.
- W99183872 magId "99183872" @default.
- W99183872 workType "article" @default.