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- W992017291 abstract "Publisher Summary This chapter reviews that accumulation of antibiotics by bacteria has, in the past, appeared to be a paradox because it was believed that few drugs could use transport systems involved in uptake of essential solutes. Several examples of antibiotics, which behave in this manner have been described. The situation is not only confined to antibiotics, because various heavy metal ions are also accumulated by systems that usually function to transport essential ions. The potentiation of fosfomycin activity in infected mice by coadministration of glucose 6-phosphate is demonstrated in the chapter. This resulted in induction of uhpT in the bacteria within the animal and increased transport of drug into the microorganisms. Another promising approach involves transport of antibiotics linked to natural substrates, so that the transport system is misused by the adduct. Although some adducts may have chemotherapeutic potential, other hybrid molecules may prove ineffective because they will become too bulky for transport. This may be particularly critical for Gram-negative bacteria where the exclusion limit for passive diffusion through outer membrane porins is usually about 600 daltons." @default.
- W992017291 created "2016-06-24" @default.
- W992017291 creator A5044018267 @default.
- W992017291 creator A5061853082 @default.
- W992017291 date "1982-01-01" @default.
- W992017291 modified "2023-10-14" @default.
- W992017291 title "Transport of Antibiotics into Bacteria" @default.
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