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- W99207100 abstract "Transcription factors of the interferon (IFN) regulatory factor (IRF) family have been shown to play an essential role in the regulated expression of type I IFN genes, IFN-stimulated genes (ISG), and other cytokines and chemokines. Three members of the IRF family, IRF-3, IRF-5, and IRF-7, have been identified as acting as direct transducers of virus-mediated signaling. In infected cells, these factors are activated by phosphorylation on the serine residues, transported to the nucleus, where they bind to the promoters of IFNA and IFNB genes and tether histone transacetylases to the transcription complex enhanceosome. IFNB and IFNA subtypes are expressed at different levels in infected cells. The ratio between the relative levels of IRF-3 and IRF-7 was shown to play an essential role in the inducible expression of type I IFN genes, whereas IRF-3 alone is sufficient for expression of the IFNB gene. IRF-5 was identified recently as another inducer of IFNA genes, which has two unique properties: (1) its activation is virus specific, and (2) the profile of IFNA genes induced by IRF-5 is distinct from that induced by IRF-7. Several viruses target functions of IRF to eliminate the early inflammatory response. Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of four genes with homology to cellular IRF. Three of these vIRF were shown to inhibit induction of IFN genes and ISG in infected cells and function as dominant negative mutants of cellular IRF. The unique properties of previously uncharacterized vIRF-2 and vIRF-3 are discussed." @default.
- W99207100 created "2016-06-24" @default.
- W99207100 creator A5009268355 @default.
- W99207100 creator A5039478606 @default.
- W99207100 creator A5042412815 @default.
- W99207100 date "2002-01-01" @default.
- W99207100 modified "2023-10-05" @default.
- W99207100 title "Review: On the Role of IRF in Host Defense" @default.
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- W99207100 doi "https://doi.org/10.1089/107999002753452665" @default.
- W99207100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11846976" @default.
- W99207100 hasPublicationYear "2002" @default.
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