FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W99213633> ?p ?o ?g. }

• W99213633 endingPage "800" @default.
• W99213633 startingPage "794" @default.
• W99213633 abstract "Abstract We have retrospectively assessed the neurological manifestations in 34 patients with hemophagocytic lymphohistiocytosis (HLH) in a single center. Clinical, radiological, and cerebrospinal fluid (CSF ) cytology data were analyzed according to treatment modalities. Twenty-five patients (73%) had evidence of central nervous system (CNS) disease at time of diagnosis, stressing the frequency of CNS involvement early in the time course of HLH. Four additional patients who did not have initial CNS disease, who did not die early from HLH complications, and who were not transplanted, also developed a specific CNS disease. Therefore, all surviving and nontransplanted patients had CNS involvement. Initially, CNS manifestations consisted of isolated lymphocytic meningitis in 20 patients and meningitis with clinical and radiological neurological symptoms in nine patients. For these nine patients, neurological symptoms consisted of seizures, coma, brain stem symptoms, or ataxia. The outcome of patients treated by systemic and intrathecal chemotherapy and/or immunosuppression exclusively (n = 16) was poor, as all died following occurrence of multiple relapses or CNS disease progression in most cases. Bone marrow transplantation (BMT) from either an HLA identical sibling (n = 6) or haplo identical parent (n = 3) was performed in nine patients, once first remission of CNS and systemic disease was achieved. Seven are long-term survivors including three who received an HLA partially identical marrow. All seven are off treatment with normal neurological function and cognitive development. In four other patients, BMT performed following CNS relapses was unsuccessful. Given the frequency and the poor outcome of CNS disease in HLH, BMT appears, therefore, to be the only available treatment procedure that is capable of preventing HLH CNS disease progression and that can result in cure when performed early enough after remission induction." @default.
• W99213633 created "2016-06-24" @default.
• W99213633 creator A5029004287 @default.
• W99213633 creator A5051621566 @default.
• W99213633 creator A5065464020 @default.
• W99213633 creator A5069822100 @default.
• W99213633 creator A5079349842 @default.
• W99213633 creator A5079991037 @default.
• W99213633 date "1997-02-01" @default.
• W99213633 modified "2023-09-28" @default.
• W99213633 title "Frequency and Severity of Central Nervous System Lesions in Hemophagocytic Lymphohistiocytosis" @default.
• W99213633 cites W1571485493 @default.
• W99213633 cites W161302449 @default.
• W99213633 cites W18302792 @default.
• W99213633 cites W1909467642 @default.
• W99213633 cites W1967985710 @default.
• W99213633 cites W1969029131 @default.
• W99213633 cites W1980045266 @default.
• W99213633 cites W2000454164 @default.
• W99213633 cites W2016104724 @default.
• W99213633 cites W2018317401 @default.
• W99213633 cites W2021594614 @default.
• W99213633 cites W2027299447 @default.
• W99213633 cites W2029303244 @default.
• W99213633 cites W2048520028 @default.
• W99213633 cites W2056196631 @default.
• W99213633 cites W2078136980 @default.
• W99213633 cites W2112242943 @default.
• W99213633 cites W2153728910 @default.
• W99213633 cites W2272631340 @default.
• W99213633 cites W2317117822 @default.
• W99213633 cites W2337969406 @default.
• W99213633 cites W2406118456 @default.
• W99213633 cites W2885046472 @default.
• W99213633 cites W4238505416 @default.
• W99213633 cites W4251814963 @default.
• W99213633 doi "https://doi.org/10.1182/blood.v89.3.794" @default.
• W99213633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9028310" @default.
• W99213633 hasPublicationYear "1997" @default.
• W99213633 type Work @default.
• W99213633 sameAs 99213633 @default.
• W99213633 citedByCount "222" @default.
• W99213633 countsByYear W992136332012 @default.
• W99213633 countsByYear W992136332013 @default.
• W99213633 countsByYear W992136332014 @default.
• W99213633 countsByYear W992136332015 @default.
• W99213633 countsByYear W992136332016 @default.
• W99213633 countsByYear W992136332017 @default.
• W99213633 countsByYear W992136332018 @default.
• W99213633 countsByYear W992136332019 @default.
• W99213633 countsByYear W992136332020 @default.
• W99213633 countsByYear W992136332021 @default.
• W99213633 countsByYear W992136332022 @default.
• W99213633 countsByYear W992136332023 @default.
• W99213633 crossrefType "journal-article" @default.
• W99213633 hasAuthorship W99213633A5029004287 @default.
• W99213633 hasAuthorship W99213633A5051621566 @default.
• W99213633 hasAuthorship W99213633A5065464020 @default.
• W99213633 hasAuthorship W99213633A5069822100 @default.
• W99213633 hasAuthorship W99213633A5079349842 @default.
• W99213633 hasAuthorship W99213633A5079991037 @default.
• W99213633 hasBestOaLocation W992136331 @default.
• W99213633 hasConcept C126322002 @default.
• W99213633 hasConcept C187212893 @default.
• W99213633 hasConcept C2779079688 @default.
• W99213633 hasConcept C2779134260 @default.
• W99213633 hasConcept C2780252810 @default.
• W99213633 hasConcept C529278444 @default.
• W99213633 hasConcept C71924100 @default.
• W99213633 hasConceptScore W99213633C126322002 @default.
• W99213633 hasConceptScore W99213633C187212893 @default.
• W99213633 hasConceptScore W99213633C2779079688 @default.
• W99213633 hasConceptScore W99213633C2779134260 @default.
• W99213633 hasConceptScore W99213633C2780252810 @default.
• W99213633 hasConceptScore W99213633C529278444 @default.
• W99213633 hasConceptScore W99213633C71924100 @default.
• W99213633 hasIssue "3" @default.
• W99213633 hasLocation W992136331 @default.
• W99213633 hasOpenAccess W99213633 @default.
• W99213633 hasPrimaryLocation W992136331 @default.
• W99213633 hasRelatedWork W1530342027 @default.
• W99213633 hasRelatedWork W1985716506 @default.
• W99213633 hasRelatedWork W1997683873 @default.
• W99213633 hasRelatedWork W2014222542 @default.
• W99213633 hasRelatedWork W2017462031 @default.
• W99213633 hasRelatedWork W2064145833 @default.
• W99213633 hasRelatedWork W2103670379 @default.
• W99213633 hasRelatedWork W2374525805 @default.
• W99213633 hasRelatedWork W4241767155 @default.
• W99213633 hasRelatedWork W4256142038 @default.
• W99213633 hasVolume "89" @default.
• W99213633 isParatext "false" @default.
• W99213633 isRetracted "false" @default.
• W99213633 magId "99213633" @default.
• W99213633 workType "article" @default.