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- W99221279 abstract "In addition to upregulation of inflammatory mediators, patients on hemodialysis due to end stage renal disease (ESRD) are periodically exposed to heparin and contact activation due to procedural settings. Recently the presence of oversulfated chondroitin sulfate in heparin was linked with adverse reactions and deaths in these patients. We measured C5a anaphylatoxin and bradykinin levels in ESRD patients prior to and after maintenance hemodialysis and in a control group of 40 normal healthy individuals. C5a and bradykinin levels were elevated in pre-dialysis samples (C5a: 14.2± 4.6 vs. 3.2±0.6 ng/ml, bradykinin: 9.3±2.4 vs. 4±1.8 ng/ml). Dialysis itself increased both C5a and bradykinin levels. The postdialysis samples were further increased, suggesting that dialysis and heparinization result in the up-regulation of these mediators. Supplementation of heparin, contaminated heparin or isolated contaminant to the plasma also resulted in the generation of C5a and bradykinin. The plasma samples included in these studies were obtained from patients who were not treated with contaminated heparin. These results suggest that C5a and bradykinin are up-regulated in ESRD patients and this level can be further augmented by dialysis and heparinization. Therefore, additional factors may have contributed to the complex adverse reaction profiles and deaths in patients administrated contaminated heparin." @default.
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- W99221279 date "2009-04-01" @default.
- W99221279 modified "2023-09-23" @default.
- W99221279 title "Increased Anaphylatoxin (C5a) and Bradykinin Levels in Patients with End‐Stage Renal Disease on Maintenance Hemodialysis: Potential Relevance to Heparin Mediated Hemodynamic Responses" @default.
- W99221279 doi "https://doi.org/10.1096/fasebj.23.1_supplement.569.5" @default.
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