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• W99231620 abstract "The hemodynamic perturbation related to patent ductus arteriosus (PDA) is associated with a higher risk of necrotizing enterocolitis (NEC).To determine whether primary surgical closure, as compared with treatment with indomethacin or exposure to prophylactic indomethacin, reduces the incidence of NEC in preterm infants <1500 g and/or ≤32 weeks' gestation with clinically and echocardiogram-identified PDA.The literature was reviewed using the methodology for systematic reviews for the Consensus of Science adapted from the American Heart Association's International Liaison Committee on Resuscitation.Ten studies were reviewed. The incidence of NEC was not lower in infants who underwent primary surgery for closure of the PDA compared with infants treated with indomethacin or infants exposed to prophylactic indomethacin (level of evidence 2).Primary surgical closure of the PDA cannot be recommended as an intervention to decrease the incidence of NEC in infants <1500 g and/or ≤32 weeks' gestation.The hemodynamic perturbation related to patent ductus arteriosus (PDA) is associated with a higher risk of necrotizing enterocolitis (NEC).To determine whether primary surgical closure, as compared with treatment with indomethacin or exposure to prophylactic indomethacin, reduces the incidence of NEC in preterm infants <1500 g and/or ≤32 weeks’ gestation with clinically and echocardiogram-identified PDA.The literature was reviewed using the methodology for systematic reviews for the Consensus of Science adapted from the American Heart Association’s International Liaison Committee on Resuscitation.Ten studies were reviewed. The incidence of NEC was not lower in infants who underwent primary surgery for closure of the PDA compared with infants treated with indomethacin or infants exposed to prophylactic indomethacin (level of evidence 2).Primary surgical closure of the PDA cannot be recommended as an intervention to decrease the incidence of NEC in infants <1500 g and/or ≤32 weeks’ gestation.La perturbation hémodynamique liée à la persistance du canal artériel (PCA) s’associe à un risque plus élevé d’entérocolite nécrosante (ECN).Déterminer si la fermeture chirurgicale primaire par rapport au traitement à l’indométhacine ou à l’exposition à une prophylaxie à l’indométhacine réduit l’incidence d’ECN chez les prématurés de moins de 1 500 g ou d’un maximum de 32 semaines d’âge gestationnel ayant une PCA diagnostiquée sur le plan clinique et par échocardiogramme.Les chercheurs ont analysé les publications au moyen de la méthodologie des analyses systématiques pour le Consensus of Science adaptées du comité de liaison internationale sur la réanimation de l’American Heart Association.Les chercheurs ont analysé dix études. L’incidence d’ECN n’était pas plus faible chez les nourrissons qui avaient subi une chirurgie primaire pour fermer une PCA que chez les nourrissons traités à l’indométhacine ou exposés à une prophylaxie à l’indométhacine (qualité des preuves 2).La fermeture chirurgicale primaire de la PCA ne peut être recommandée pour réduire l’incidence d’ECN chez les nourrissons de moins de 1 500 g ou d’un maximum de 32 semaines d’âge gestationnel." @default.
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• W99231620 date "2012-03-01" @default.
• W99231620 modified "2023-09-24" @default.
• W99231620 title "Does primary surgical closure of the patent ductus arteriosus in infants <1500 g or ≤32 weeks’ gestation reduce the incidence of necrotizing enterocolitis?" @default.
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• W99231620 doi "https://doi.org/10.1093/pch/17.3.125" @default.
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