Matches in SemOpenAlex for { <https://semopenalex.org/work/W99274590> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W99274590 abstract "LR11, also called SORLA, is a 250-kDa single transmembrane receptor, belonging to both LDL-receptor and Vps10p receptor family. LR11 is abundantly and specifically expressed in intima smooth muscle cells and regulates its migration. Plasma soluble form of LR11 (sLR11) is positively correlated with the intima-media thickness and has been promoted as a risk factor for coronary artery disease (CAD). Here we studied the role of LR11 in lipid-related gene expression and CAD development, using both Familial Hypercholesterolemia (FH) patients and animal models. LDLR-KO and ApoE-KO mice were fed with either chow or Western type diet (WTD) and their livers were examined. LR11 mRNA and protein expression were elevated in LDLR-KO mice on chow diet but not in ApoE-KO, compared to wild-type controls. WTD further increased LR11 level in both KO strains. SORT1, another Vps10p family member, expression was decreased only in LDLR-KO fed with WTD. To further elucidate the effect of diet, human hepatocytes and hepatic stellate cells were exposed to chylomicrons, LDL and crude fish oil. Chylomicrons increased LR11 mRNA expression in hepatocytes but not stellate cells. For human study, fasting plasma of adult FH patients with and without CAD when ‘off’ statin and of their healthy non-FH brothers were collected. Plasma sLR11 level of FH with CAD is higher when compared to their healthy brothers while no difference was shown in FH without CAD compared to their healthy brothers. A similar trend was observed in plasma sLR11 of LDLR-KO mice on chow diet. We concluded that LR11 is upregulated in an absence of LDL receptor which is markedly affected by diet and triglyceride-rich lipoprotein showed a similar effect in an in vitro setting. Plasma sLR11 correlated with the development of atherosclerosis/CAD. sLR11 may be used as an additional risk factor for CAD in FH patients." @default.
- W99274590 created "2016-06-24" @default.
- W99274590 creator A5004322317 @default.
- W99274590 creator A5030377588 @default.
- W99274590 creator A5035797354 @default.
- W99274590 creator A5036385467 @default.
- W99274590 creator A5045683286 @default.
- W99274590 creator A5051857451 @default.
- W99274590 date "2012-11-20" @default.
- W99274590 modified "2023-09-23" @default.
- W99274590 title "Abstract 15600: Roles of LR11 Receptor in Atherosclerosis Development of Familial Hypercholesterolemia Subjects" @default.
- W99274590 hasPublicationYear "2012" @default.
- W99274590 type Work @default.
- W99274590 sameAs 99274590 @default.
- W99274590 citedByCount "0" @default.
- W99274590 crossrefType "journal-article" @default.
- W99274590 hasAuthorship W99274590A5004322317 @default.
- W99274590 hasAuthorship W99274590A5030377588 @default.
- W99274590 hasAuthorship W99274590A5035797354 @default.
- W99274590 hasAuthorship W99274590A5036385467 @default.
- W99274590 hasAuthorship W99274590A5045683286 @default.
- W99274590 hasAuthorship W99274590A5051857451 @default.
- W99274590 hasConcept C11772777 @default.
- W99274590 hasConcept C126322002 @default.
- W99274590 hasConcept C134018914 @default.
- W99274590 hasConcept C170493617 @default.
- W99274590 hasConcept C2778163477 @default.
- W99274590 hasConcept C2778213512 @default.
- W99274590 hasConcept C2779120738 @default.
- W99274590 hasConcept C2780072125 @default.
- W99274590 hasConcept C43554185 @default.
- W99274590 hasConcept C62746215 @default.
- W99274590 hasConcept C71924100 @default.
- W99274590 hasConcept C8243546 @default.
- W99274590 hasConceptScore W99274590C11772777 @default.
- W99274590 hasConceptScore W99274590C126322002 @default.
- W99274590 hasConceptScore W99274590C134018914 @default.
- W99274590 hasConceptScore W99274590C170493617 @default.
- W99274590 hasConceptScore W99274590C2778163477 @default.
- W99274590 hasConceptScore W99274590C2778213512 @default.
- W99274590 hasConceptScore W99274590C2779120738 @default.
- W99274590 hasConceptScore W99274590C2780072125 @default.
- W99274590 hasConceptScore W99274590C43554185 @default.
- W99274590 hasConceptScore W99274590C62746215 @default.
- W99274590 hasConceptScore W99274590C71924100 @default.
- W99274590 hasConceptScore W99274590C8243546 @default.
- W99274590 hasOpenAccess W99274590 @default.
- W99274590 hasRelatedWork W1963166572 @default.
- W99274590 hasRelatedWork W1973348500 @default.
- W99274590 hasRelatedWork W1987525850 @default.
- W99274590 hasRelatedWork W1996196306 @default.
- W99274590 hasRelatedWork W1996548712 @default.
- W99274590 hasRelatedWork W2019345011 @default.
- W99274590 hasRelatedWork W2076522499 @default.
- W99274590 hasRelatedWork W2144050182 @default.
- W99274590 hasRelatedWork W2183463322 @default.
- W99274590 hasRelatedWork W2294849258 @default.
- W99274590 hasRelatedWork W2405406969 @default.
- W99274590 hasRelatedWork W2574261439 @default.
- W99274590 hasRelatedWork W2587676663 @default.
- W99274590 hasRelatedWork W2610746980 @default.
- W99274590 hasRelatedWork W2794488214 @default.
- W99274590 hasRelatedWork W2889692639 @default.
- W99274590 hasRelatedWork W2994497119 @default.
- W99274590 hasRelatedWork W3149930415 @default.
- W99274590 hasRelatedWork W3165159230 @default.
- W99274590 hasRelatedWork W66390214 @default.
- W99274590 hasVolume "126" @default.
- W99274590 isParatext "false" @default.
- W99274590 isRetracted "false" @default.
- W99274590 magId "99274590" @default.
- W99274590 workType "article" @default.