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- W99295697 abstract "Over the past fifteen years selective serotonin uptake inhibitors such as fluoxetine, sertraline, citalopram, paroxetine, and litoxetine have been developed, some of which are currently widely used in the clinical management of affective disorders. These selective uptake inhibitors have provided powerful probes to undertake molecular pharmacological studies of the sodium-ion coupled serotonin transporter. Using affinity-chromatography purification the rat brain serotonin transporter was identified as a polypeptide of Mr = 73,000. In addition, PCR technology recently enabled the cloning of this transporter polypeptide which now opens up exciting perspectives for further fundamental and clinical research on this transport system." @default.
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- W99295697 date "1993-01-01" @default.
- W99295697 modified "2023-09-23" @default.
- W99295697 title "Inhibitors of Serotonin Uptake" @default.
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