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- W993011896 endingPage "289" @default.
- W993011896 startingPage "287" @default.
- W993011896 abstract "目的 研究多囊卵巢综合（Polycystic ovary syndrome，PCOS）患者脂肪组织胰岛素受体底物-1（Insulin receptor substeate-1，IRS-1）及胰岛素受体底物-2（Insulin receptor substeate-2，IRS-2）蛋白的表达，探讨PCOS产生胰岛素抵抗（Insulinresistance，IR）的分子机制。方法采用放射免疫法检测PCOSIR组（20例）、PCOS非IR组（15例）及对照组（20例）血清空腹胰岛素（Fasting insulin，FIN）的浓度；采用葡萄糖氧化酶法测定血浆空腹血糖（Fasting plasmaglucose，FPG）；采用HOMA（Homeostasis model assessment，HOMA）模型计算胰岛素抵抗指数（HOMA—IR）；采用Westernblot方法检测IRS-1及IRS-2蛋白的表达。结果（1）PCOSIR组患者血清FIN及HOMA—IR均显著高于PCOS非IR组与对照组（均P〈0．05）；PCOS非IR组患者血清FIN及HOMA—IR亦显著高于对照组（均P〈05）；（2）PCOSIR组与PCOS非IR组及对照组相比，IRS-1蛋白表达量明显下降（P〈0．05），而IRS-2蛋白表达无显著性差别。结论PCOS患者脂肪组织IRS-1蛋白表达的下降所导致的受体后信号转导障碍可能是其产生胰岛素抵抗的机制之一。" @default.
- W993011896 created "2016-06-24" @default.
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- W993011896 date "2007-01-01" @default.
- W993011896 modified "2023-09-23" @default.
- W993011896 title "IRS-1IRS-2蛋白质在PCOS患者脂肪组织中的表达" @default.
- W993011896 hasPublicationYear "2007" @default.
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