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- W993065130 abstract "The migration of leukocytes out of the blood into inflamed tissues involves activation of leukocytes and vascular endothelial cells (ECs) and adhesive events between these two types of cells that promote the passage of the leukocyte out of the blood vessel. In the past few years, there has been a dramatic increase in our understanding of this complex process, with multiple new receptor interactions being identified and activation induced changes being discovered. The selectin family of molecules, found on both leukocytes and endothelium, are adhesive lectins that mediate one of the earliest steps in leukocyte contact with ECs and may promote leukocyte activation (Lasky 1991). In a number of models, leukocyte integrins appear to act at a second stage to greatly enhance leukocyte EC adhesion allowing the migration of the leukocyte along the EC and between ECs to the extracellular space (Von Andrian etal. 1991; Lawrence and Springer 1991; Butcher 1991). This adhesion is mediated by two groups of integrins: (1) the β 2 integrins αxβ2 (CD11 a/CD18), αMβ2(CD11b/CD18) and αxβ2(CD11c/CD18), and (2) the α4 integrins α4β1 (CD49d/CD29) and α4β7. CD11a/CD18, also known as LFA-1, can bind to intracellular adhesion molecule-1 (ICAM-1) (Marlin and Springer 1987), ICAM-2 (De Fougerolles etal. 1991; Nortamo etal. 1991a), and ICAM-3 (De Fougerollesand Springer 1992) which are members of the immunoglobulin (Ig) supergene family." @default.
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- W993065130 date "1993-01-01" @default.
- W993065130 modified "2023-10-11" @default.
- W993065130 title "The Contributions of Integrins to Leukocyte Infiltration in Inflamed Tissues" @default.
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- W993065130 doi "https://doi.org/10.1007/978-3-642-78253-4_14" @default.
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