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- W993298506 abstract "1.1. Two cases of small choriocarcinomas located within otherwise normal placentas are presented. 2.2. The origin of choriocarcinoma from normal formed villi is shown. 3.3. Spontaneous degeneration of the abnormal trophoblast and of the formed villi in the primary site is a characteristic feature of choriocarcinoma. This degeneration within the masses of trophoblast projecting into the intervillous space may play a part in the readiness with which trophoblastic fragments without villi gain access to the myometrial veins. Extensive degeneration involves the formed villi and accounts, in the main, for their loss and complete absence in more advanced lesions. 4.4. In these two specimens the malignant trophoblast is in direct contact with the endothelium of fetal capillaries but does not destroy it, or invade the capillary, in marked contrast to the great affinity of trophoblast to destroy and invade maternal blood vessels. 5.5. In early stages of choriocarcinoma three of the criteria required for the diagnosis are lacking, namely, absence of villi, and hemorrhage into and necrosis of maternal tissue." @default.
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- W993298506 date "1966-03-01" @default.
- W993298506 modified "2023-10-09" @default.
- W993298506 title "Early development of choriocarcinoma" @default.
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- W993298506 doi "https://doi.org/10.1016/0002-9378(66)90402-9" @default.
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