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- W993359079 abstract "Objective:To investigate immunological function in acute phase of Henoch-Schonlein purpura (HSP) in children. Methods: 46 children with HSP in acute phase were enrolled in this study and 30 healthy children were control group. CD3, CD4, CD8, CDI9, and CDI6+56 expression on the surface of peripheral blood lymphocytes were analyzed by flow cytometry, the serum levels of IgA, IgG, IgM and the complement C3, C4 were detected by automatic biochemistry analyzer. Results: CD4 cell, CD16+56 cell and ratio of CD4/CD8 in HSP group were significantly lower than those in control group (P0.05 or P0.01), CD8, CD19 cell was significantly higher than that in control group (P0.05). During the acute phase of the disease in 36/46 patients (78.3%) immunological imbalances were observed. In 16/36 cases (44.4%) certain complications involving the kidneys and the gastrointestinal tract were noted as opposed to in 2/10 children (20.0%) without immunologic abnormalities (P0.05). In 32/46 children (69.6%), elevated serum IgA was detected and 10/32 patients (31.3% ) developed renal involvement while only 1/14 children (7.1% ) with normal IgA concentration had renal involvement (P0.01). Conclusions: There are disorders of cellular and humoral immune in acute HSP. Patients of HSP with increased IgA concentration are prone to kidney or digestive tract complications." @default.
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- W993359079 date "2009-01-01" @default.
- W993359079 modified "2023-09-23" @default.
- W993359079 title "Changes of immunological indicators in acute phase of Henoch-Schonlein purpura in children and its significance." @default.
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