Matches in SemOpenAlex for { <https://semopenalex.org/work/W993364412> ?p ?o ?g. }
- W993364412 endingPage "1438" @default.
- W993364412 startingPage "1430" @default.
- W993364412 abstract "The adenosine triphosphate-binding cassette transporter A1 (ABCA1) is a major cholesterol transporter highly expressed in the liver and brain. In the brain, ABCA1 lipidates apolipoprotein E (apoE), facilitates clearance of amyloid-β, and may be involved in maintenance of the blood-brain barrier via apoE-mediated pathways.We tested whether a loss-of-function mutation in ABCA1, N1800H, is associated with plasma levels of apoE and with risk of Alzheimer's disease (AD) in 92,726 individuals and with risk of cerebrovascular disease in 64,181 individuals.N1800H AC (0.2%) versus AA (99.8%) was associated with a 13% lower plasma level of apoE (P = 1 × 10(-11)). Multifactorially adjusted hazard ratios for N1800H AC versus AA were 4.13 (95% confidence interval, 1.32-12.9) for AD, 2.46 (1.10-5.50) for cerebrovascular disease, and 8.28 (2.03-33.7) for the hemorrhagic stroke subtype.A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE and with high risk of AD and cerebrovascular disease in the general population." @default.
- W993364412 created "2016-06-24" @default.
- W993364412 creator A5022615366 @default.
- W993364412 creator A5067228009 @default.
- W993364412 creator A5079728437 @default.
- W993364412 creator A5081108450 @default.
- W993364412 date "2015-06-13" @default.
- W993364412 modified "2023-10-05" @default.
- W993364412 title "Loss‐of‐function mutation in <i>ABCA1</i> and risk of Alzheimer's disease and cerebrovascular disease" @default.
- W993364412 cites W1568306988 @default.
- W993364412 cites W1630163149 @default.
- W993364412 cites W1671478575 @default.
- W993364412 cites W1966223335 @default.
- W993364412 cites W1989076425 @default.
- W993364412 cites W1991166529 @default.
- W993364412 cites W2000426341 @default.
- W993364412 cites W2006035554 @default.
- W993364412 cites W2013111251 @default.
- W993364412 cites W2015849111 @default.
- W993364412 cites W2017961719 @default.
- W993364412 cites W2022802489 @default.
- W993364412 cites W2023271730 @default.
- W993364412 cites W2030137882 @default.
- W993364412 cites W2030667927 @default.
- W993364412 cites W2031762899 @default.
- W993364412 cites W2036362108 @default.
- W993364412 cites W2037590491 @default.
- W993364412 cites W2038981426 @default.
- W993364412 cites W2040922047 @default.
- W993364412 cites W2050195566 @default.
- W993364412 cites W2052644460 @default.
- W993364412 cites W2052764851 @default.
- W993364412 cites W2054246200 @default.
- W993364412 cites W2067236303 @default.
- W993364412 cites W2081615427 @default.
- W993364412 cites W2093381644 @default.
- W993364412 cites W2099248872 @default.
- W993364412 cites W2099853999 @default.
- W993364412 cites W2100948379 @default.
- W993364412 cites W2102736631 @default.
- W993364412 cites W2103025142 @default.
- W993364412 cites W2110755749 @default.
- W993364412 cites W2115017507 @default.
- W993364412 cites W2115779804 @default.
- W993364412 cites W2116404316 @default.
- W993364412 cites W2122589739 @default.
- W993364412 cites W2124481332 @default.
- W993364412 cites W2124490243 @default.
- W993364412 cites W2124927590 @default.
- W993364412 cites W2128613449 @default.
- W993364412 cites W2138992210 @default.
- W993364412 cites W2151049459 @default.
- W993364412 cites W4236012903 @default.
- W993364412 cites W4247759744 @default.
- W993364412 doi "https://doi.org/10.1016/j.jalz.2015.04.006" @default.
- W993364412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26079414" @default.
- W993364412 hasPublicationYear "2015" @default.
- W993364412 type Work @default.
- W993364412 sameAs 993364412 @default.
- W993364412 citedByCount "103" @default.
- W993364412 countsByYear W9933644122016 @default.
- W993364412 countsByYear W9933644122017 @default.
- W993364412 countsByYear W9933644122018 @default.
- W993364412 countsByYear W9933644122019 @default.
- W993364412 countsByYear W9933644122020 @default.
- W993364412 countsByYear W9933644122021 @default.
- W993364412 countsByYear W9933644122022 @default.
- W993364412 countsByYear W9933644122023 @default.
- W993364412 crossrefType "journal-article" @default.
- W993364412 hasAuthorship W993364412A5022615366 @default.
- W993364412 hasAuthorship W993364412A5067228009 @default.
- W993364412 hasAuthorship W993364412A5079728437 @default.
- W993364412 hasAuthorship W993364412A5081108450 @default.
- W993364412 hasConcept C104317684 @default.
- W993364412 hasConcept C126322002 @default.
- W993364412 hasConcept C127413603 @default.
- W993364412 hasConcept C134018914 @default.
- W993364412 hasConcept C149011108 @default.
- W993364412 hasConcept C207103383 @default.
- W993364412 hasConcept C2777704780 @default.
- W993364412 hasConcept C2779134260 @default.
- W993364412 hasConcept C2779483572 @default.
- W993364412 hasConcept C2780645631 @default.
- W993364412 hasConcept C2908647359 @default.
- W993364412 hasConcept C44249647 @default.
- W993364412 hasConcept C502032728 @default.
- W993364412 hasConcept C54355233 @default.
- W993364412 hasConcept C57089818 @default.
- W993364412 hasConcept C71924100 @default.
- W993364412 hasConcept C78519656 @default.
- W993364412 hasConcept C86803240 @default.
- W993364412 hasConcept C99454951 @default.
- W993364412 hasConceptScore W993364412C104317684 @default.
- W993364412 hasConceptScore W993364412C126322002 @default.
- W993364412 hasConceptScore W993364412C127413603 @default.
- W993364412 hasConceptScore W993364412C134018914 @default.
- W993364412 hasConceptScore W993364412C149011108 @default.
- W993364412 hasConceptScore W993364412C207103383 @default.