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• W99346862 abstract "Chapter Summary Maternofetal exchange across the mouse placenta takes place by similar mechanisms to other species. These are (1) bulk flow/solvent drag; (2) flow and membrane limited transfer; (3) transporter protein mediated transfer; and (4) endocytosis/exocytosis. Nothing is yet known about (1) in the mouse. As regards (2) in vivo measurements of transfer of inert hydrophilic solutes suggest that the diffusional permeability of the mouse placenta is similar to that of other hemochorial placentas. Regarding (3), expression and activity of a number of transporter proteins have been characterized in the mouse, and these are qualitatively similar to those found in humans, although one transporter (for taurine) shows much lower expression and activity. Regarding (4), transfer of immunoglobulin G predominantly occurs via the choriovitelline placenta in the mouse utilizing the FcRn receptor and an endocytosis/exocytosis pathway similar to that in human chorioallantoic placenta. Several key gaps in knowledge are summarized." @default.
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• W99346862 date "2014-01-01" @default.
• W99346862 modified "2023-09-27" @default.
• W99346862 title "Physiological Exchange across Mouse Placenta" @default.
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• W99346862 doi "https://doi.org/10.1016/b978-0-12-394445-0.00017-5" @default.
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