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• W993588088 abstract "The hepatitis C virus (HCV) NS3/4A protease that plays an important role in the viral life cycle has been proven to be an excellent target for the discovery of anti-HCV drugs. Enlightened by some P2-triazole and amide compounds, which had been found as HCV NS3 protease inhibitors, we designed and synthesized a series of novel compounds by incorporating different amino acid residues in P1/P1' and P3/P3' position to develop novel antiviral agents. The result of enzyme inhibition assay indicated that all the designed compounds showed moderate anti-HCV NS3 protease activity. On the basis of the biological result, a detailed structure-activity relationship (SAR) was derived and discussed." @default.
• W993588088 created "2016-06-24" @default.
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• W993588088 date "2015-09-01" @default.
• W993588088 modified "2023-10-17" @default.
• W993588088 title "Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro" @default.
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• W993588088 doi "https://doi.org/10.1016/j.bmc.2015.07.032" @default.
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