Matches in SemOpenAlex for { <https://semopenalex.org/work/W993662799> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W993662799 abstract "Taurine increases in the zone surrounding a thrombotic infarct which could be prevented by a neuroprotective drug. Therefore, we aimed at studying the possible release mechanisms since the monitoring of taurine might give valuable information on the progress of cerebral insults and the effect of drugs. A microdialysis membrane was implanted into the cortex of anaesthetised rats: As toxic triggers possibly released by the dying cells in the peri-infarct zone, either a glutamatergic agonist (NMDA) or high potassium were applied via the microdialysis probe. Alternatively, a diluted perfusate was applied to induce cell swelling directly. NMDA antagonists or the NO synthase inhibitor L-NAME were applied locally too. NMDA, NO, high potassium or the hypotonic solution stimulated the release of taurine. The effect of high potassium could be prevented by Ketamine, but not by APV. The effect of NMDA could be inhibited by APV or Ketamine or the NO synthase inhibitor L-NAME. The release of taurine induced by the hypotonic solution could not be be reduced by any of the inhibitors. These data suggest that the release of taurine induced by glutamatergic activity is mediated via the NO cascade. The potassium mediated release seems to be related only in part to glutamatergic activity. Thus, other mechanisms seem to be predominate in potassium mediated swelling. Hypoosmotically induced taurine release is not mediated via the NO cascade and also seems to differ from the aforementioned release mechanisms.Monitoring of extracellular taurine allows to follow pathological events and to differentiate drug effects." @default.
- W993662799 created "2016-06-24" @default.
- W993662799 creator A5014005682 @default.
- W993662799 date "2002-01-01" @default.
- W993662799 modified "2023-09-27" @default.
- W993662799 title "Extracellular Taurine as a Parameter to Monitor Cerebral Insults ‘On-Line’" @default.
- W993662799 cites W1966930486 @default.
- W993662799 cites W1999857682 @default.
- W993662799 cites W2012608223 @default.
- W993662799 cites W2017288380 @default.
- W993662799 cites W2076876715 @default.
- W993662799 cites W2100453073 @default.
- W993662799 cites W938784933 @default.
- W993662799 doi "https://doi.org/10.1007/0-306-46838-7_29" @default.
- W993662799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11787606" @default.
- W993662799 hasPublicationYear "2002" @default.
- W993662799 type Work @default.
- W993662799 sameAs 993662799 @default.
- W993662799 citedByCount "1" @default.
- W993662799 crossrefType "book-chapter" @default.
- W993662799 hasAuthorship W993662799A5014005682 @default.
- W993662799 hasConcept C169760540 @default.
- W993662799 hasConcept C170493617 @default.
- W993662799 hasConcept C185592680 @default.
- W993662799 hasConcept C2779701627 @default.
- W993662799 hasConcept C2780648746 @default.
- W993662799 hasConcept C28406088 @default.
- W993662799 hasConcept C50156730 @default.
- W993662799 hasConcept C515207424 @default.
- W993662799 hasConcept C55493867 @default.
- W993662799 hasConcept C61174792 @default.
- W993662799 hasConcept C67018056 @default.
- W993662799 hasConcept C86803240 @default.
- W993662799 hasConcept C98274493 @default.
- W993662799 hasConceptScore W993662799C169760540 @default.
- W993662799 hasConceptScore W993662799C170493617 @default.
- W993662799 hasConceptScore W993662799C185592680 @default.
- W993662799 hasConceptScore W993662799C2779701627 @default.
- W993662799 hasConceptScore W993662799C2780648746 @default.
- W993662799 hasConceptScore W993662799C28406088 @default.
- W993662799 hasConceptScore W993662799C50156730 @default.
- W993662799 hasConceptScore W993662799C515207424 @default.
- W993662799 hasConceptScore W993662799C55493867 @default.
- W993662799 hasConceptScore W993662799C61174792 @default.
- W993662799 hasConceptScore W993662799C67018056 @default.
- W993662799 hasConceptScore W993662799C86803240 @default.
- W993662799 hasConceptScore W993662799C98274493 @default.
- W993662799 hasLocation W9936627991 @default.
- W993662799 hasLocation W9936627992 @default.
- W993662799 hasOpenAccess W993662799 @default.
- W993662799 hasPrimaryLocation W9936627991 @default.
- W993662799 hasRelatedWork W102307410 @default.
- W993662799 hasRelatedWork W1582552785 @default.
- W993662799 hasRelatedWork W1977232474 @default.
- W993662799 hasRelatedWork W1988856653 @default.
- W993662799 hasRelatedWork W2001649286 @default.
- W993662799 hasRelatedWork W2009012981 @default.
- W993662799 hasRelatedWork W2015804688 @default.
- W993662799 hasRelatedWork W2018117293 @default.
- W993662799 hasRelatedWork W2018879527 @default.
- W993662799 hasRelatedWork W2034080248 @default.
- W993662799 hasRelatedWork W2035194438 @default.
- W993662799 hasRelatedWork W2048249071 @default.
- W993662799 hasRelatedWork W2059616097 @default.
- W993662799 hasRelatedWork W2065636160 @default.
- W993662799 hasRelatedWork W2086732639 @default.
- W993662799 hasRelatedWork W2093886877 @default.
- W993662799 hasRelatedWork W2398393335 @default.
- W993662799 hasRelatedWork W2602164361 @default.
- W993662799 hasRelatedWork W953616316 @default.
- W993662799 hasRelatedWork W9822926 @default.
- W993662799 isParatext "false" @default.
- W993662799 isRetracted "false" @default.
- W993662799 magId "993662799" @default.
- W993662799 workType "book-chapter" @default.