FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W99385905> ?p ?o ?g. }

• W99385905 endingPage "8" @default.
• W99385905 startingPage "23" @default.
• W99385905 abstract "P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of the tumor protein P53 gene (TP53) mutation in lung adenocarcinoma are indefinite. The aim of this study is to explore the clinical significance of the mutant P53 protein expression in lung adenocarcinoma tissues.The clinicopathological data of 120 lung adenocarcinoma patients who underwent surgery were retrospectively analyzed. The mutant P53 protein expression was detected using the immunohistochemical method. Furthermore, the relationship between the mutant P53 expression and the clinicopathological parameters was analyzed using the Chi-square test, whereas that between the mutant P53 expression and overall survival was estimated using the Kaplan-Meier method and Cox regression model.The mutant P53 protein expression rate was 63.3%. Accordingly, the mutant P53 expression was significantly associated with tumor size (P=0.041) and clinicopathological stage (P=0.025). On the one hand, a univariate survival analysis showed that tumor size (P=0.031), lymph node metastasis (P<0.001), clinicopathological stage (P<0.001), and mutant P53 expression (P=0.038) were associated with overall survival. On the other hand, a multivariate survival analysis showed that lymph node metastasis (P=0.014) was an independent poor prognostic factor for overall survival.Patients with lung adenocarcinoma with mutant TP53 had a poor outcome. Accordingly, the mutant P53 protein may serve as a molecular prognosis marker for lung adenocarcinoma patients.背景与目的 突变型TP53基因不仅丧失了抑癌功能，其编码的突变型P53蛋白还能获得促进细胞增殖、抑制细胞凋亡等功能。目前TP53基因在肺腺癌中突变的临床意义尚不十分明确。本研究旨在探讨突变型P53蛋白在肺腺癌组织中的表达及其临床意义。方法 回顾性分析120例肺腺癌手术患者的临床病理资料，应用免疫组化法检测患者组织标本中突变型P53蛋白的表达，采用χ2检验分析突变型P53蛋白表达与各临床病理参数的关系，采用单因素生存分析及多因素生存分析法分析突变型P53蛋白表达与总生存期的关系。结果 突变型P53蛋白在肺腺癌组织中的表达率为63.7%，突变型P53蛋白的表达与肿瘤大小（P=0.041）及病理分期（P=0.025）有关。单因素生存分析提示肿瘤大小（P=0.031）、淋巴结转移（P<0.001）、病理分期（P<0.001）以及突变型P53蛋白的表达（P=0.038）与患者总生存期密切相关。多因素生存分析提示仅有淋巴结转移（P=0.014）是患者总生存期的独立影响因素。结论 TP53基因突变的肺腺癌患者预后较差，突变型P53蛋白可以作为预测患者预后的分子标志物。" @default.
• W99385905 created "2016-06-24" @default.
• W99385905 creator A5001453048 @default.
• W99385905 creator A5053755264 @default.
• W99385905 creator A5062048182 @default.
• W99385905 creator A5070879677 @default.
• W99385905 creator A5075877965 @default.
• W99385905 creator A5089692722 @default.
• W99385905 date "2015-01-01" @default.
• W99385905 modified "2023-09-26" @default.
• W99385905 title "[Clinical significance of mutant p53 protein expression in lung adenocarcinoma]." @default.
• W99385905 cites W1971427051 @default.
• W99385905 cites W1995068068 @default.
• W99385905 cites W1997504594 @default.
• W99385905 cites W2016575939 @default.
• W99385905 cites W2018336040 @default.
• W99385905 cites W2022495797 @default.
• W99385905 cites W2027853345 @default.
• W99385905 cites W2030196526 @default.
• W99385905 cites W2039210293 @default.
• W99385905 cites W2042108179 @default.
• W99385905 cites W2042386784 @default.
• W99385905 cites W2053652371 @default.
• W99385905 cites W2054858603 @default.
• W99385905 cites W2055521585 @default.
• W99385905 cites W2071392860 @default.
• W99385905 cites W2078989706 @default.
• W99385905 cites W2106787323 @default.
• W99385905 cites W2121110745 @default.
• W99385905 cites W2129141930 @default.
• W99385905 cites W2137583207 @default.
• W99385905 cites W2153878433 @default.
• W99385905 cites W2162304782 @default.
• W99385905 cites W2162927892 @default.
• W99385905 cites W2163798887 @default.
• W99385905 doi "https://doi.org/10.3779/j.issn.1009-3419.2015.01.04" @default.
• W99385905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5999740" @default.
• W99385905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25603869" @default.
• W99385905 hasPublicationYear "2015" @default.
• W99385905 type Work @default.
• W99385905 sameAs 99385905 @default.
• W99385905 citedByCount "2" @default.
• W99385905 countsByYear W993859052019 @default.
• W99385905 countsByYear W993859052022 @default.
• W99385905 crossrefType "journal-article" @default.
• W99385905 hasAuthorship W99385905A5001453048 @default.
• W99385905 hasAuthorship W99385905A5053755264 @default.
• W99385905 hasAuthorship W99385905A5062048182 @default.
• W99385905 hasAuthorship W99385905A5070879677 @default.
• W99385905 hasAuthorship W99385905A5075877965 @default.
• W99385905 hasAuthorship W99385905A5089692722 @default.
• W99385905 hasConcept C104317684 @default.
• W99385905 hasConcept C10515644 @default.
• W99385905 hasConcept C121608353 @default.
• W99385905 hasConcept C126322002 @default.
• W99385905 hasConcept C142724271 @default.
• W99385905 hasConcept C143065580 @default.
• W99385905 hasConcept C143998085 @default.
• W99385905 hasConcept C204232928 @default.
• W99385905 hasConcept C2776256026 @default.
• W99385905 hasConcept C2776283816 @default.
• W99385905 hasConcept C2779013556 @default.
• W99385905 hasConcept C2780849966 @default.
• W99385905 hasConcept C2781182431 @default.
• W99385905 hasConcept C502942594 @default.
• W99385905 hasConcept C50382708 @default.
• W99385905 hasConcept C55493867 @default.
• W99385905 hasConcept C63363279 @default.
• W99385905 hasConcept C71924100 @default.
• W99385905 hasConcept C86803240 @default.
• W99385905 hasConceptScore W99385905C104317684 @default.
• W99385905 hasConceptScore W99385905C10515644 @default.
• W99385905 hasConceptScore W99385905C121608353 @default.
• W99385905 hasConceptScore W99385905C126322002 @default.
• W99385905 hasConceptScore W99385905C142724271 @default.
• W99385905 hasConceptScore W99385905C143065580 @default.
• W99385905 hasConceptScore W99385905C143998085 @default.
• W99385905 hasConceptScore W99385905C204232928 @default.
• W99385905 hasConceptScore W99385905C2776256026 @default.
• W99385905 hasConceptScore W99385905C2776283816 @default.
• W99385905 hasConceptScore W99385905C2779013556 @default.
• W99385905 hasConceptScore W99385905C2780849966 @default.
• W99385905 hasConceptScore W99385905C2781182431 @default.
• W99385905 hasConceptScore W99385905C502942594 @default.
• W99385905 hasConceptScore W99385905C50382708 @default.
• W99385905 hasConceptScore W99385905C55493867 @default.
• W99385905 hasConceptScore W99385905C63363279 @default.
• W99385905 hasConceptScore W99385905C71924100 @default.
• W99385905 hasConceptScore W99385905C86803240 @default.
• W99385905 hasIssue "1" @default.
• W99385905 hasLocation W993859051 @default.
• W99385905 hasLocation W993859052 @default.
• W99385905 hasOpenAccess W99385905 @default.
• W99385905 hasPrimaryLocation W993859051 @default.
• W99385905 hasRelatedWork W1606053986 @default.
• W99385905 hasRelatedWork W1955788743 @default.
• W99385905 hasRelatedWork W2080671488 @default.
• W99385905 hasRelatedWork W2142544041 @default.

• next